缺血性脑卒中血瘀证患者不同病期血浆t-PA、PAI活性及其比值临床观察

Clinical Studies on Plasma t-PA and PAI Activities and Their Ratio in Patients with Ischemic Stroke Associated with Stagnation of Blood During Various Stages

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中文关键词: 缺血性脑卒中血瘀证 t-PA PAI

英文关键词:ischemic stroke stagnation of blood tissue type plasminogen activator plasminogen activator inhibitor

基金项目:

作者	单位
韩新民	上海市浦东中心医院中西医结合研究室上海200120
茅惠明	上海市浦东中心医院中西医结合研究室上海200120
陈正权	上海市浦东中心医院中西医结合研究室上海200120
孙天庭	上海市浦东中心医院中西医结合研究室上海200120
余永敏	上海市浦东中心医院中西医结合研究室上海200120

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中文摘要:

对临床缺血性脑卒中兼有血瘀证患者按不同病期分别进行血浆 t-PA、PAI活性水平检测。结果表明,急性期 t-PA 活性增高,并可持续到临床恢复期,至后遗症期呈下降趋势;急性期 PAI 活性较健康成人低,但在恢复期发生逆转,血浆 PAI 活性升高,至临床后遗症期尤为明显。由于上述改变使 PAI/t-PA 比值在不同病期发生异常变化,后期临床血瘀证候虽有一定改善,但这一血液学异常依然存在,并可能是血栓再度形成的危险因子之一,也是缺血性脑卒中临床复发率较高的原因。

英文摘要:

The studies showed that t-PA activity was elevated during the acute phase,remained elevated during the recovery stage and declined during the sequelar stage.Lowering of PAI activity was found during the acute phase,which was reversed during the recovery phase and remained significantly elevated during the sequelar stage compared with the controls,(P<0.001),F test showed that both t-PA and PAI activities changed significantly during various stages(t-PA,P<0.01;PAI,P<0.001). Because of these changes,the ratio of PAI and t-PA fluctuated during different stages of the disease. This ratio decreased during the acute stage and came close to the normal levels during the recovery phase.The ratio,however,elevated abnormally during the sequelar stage,compared with healthy controls(P<0.05),In addition,the result of correlation test and linear regression analysis of serum t-PA and PAI activities in 54 cases showed a significant negative correlation(P<0.001)existed between t-PA and PAI activities.The balance of plasma t-PA and PAI activities have the function in maintaining the normal bloodstream in human body.In the process of disease,the abnormality of plasma t-PA and PAI activities may be the different pathological characteristics involved in this stagnation process.If coordinated with differentiation of syndromee in TCM,it may have the important significance to follow-up,and determine prognosis and eavly diagnosis for certain poten- tial clinical stagnation of blood.

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