| 虞滌霞,韩月瑛,陶辉,张敏,徐晓云,李绍白,郭冰,张文英.酚妥拉明及当归素治疗慢性活动性肝炎胆汁郁滞及慢性重症肝炎的研究[J].中国中西医结合杂志,1991,(3):135-137,131 |
| 酚妥拉明及当归素治疗慢性活动性肝炎胆汁郁滞及慢性重症肝炎的研究 |
| Combination of Phentolamine and Angelicini in Cholestasis and Severe Type of Chronic Active Hepatitis B |
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| DOI： |
| 中文关键词: 酚妥拉明 当归素 慢性活动性肝炎 胆汁郁滞 慢性重症肝炎 |
| 英文关键词:phentolamine angelicini cholestasis chronic active hepatitis chronic severs hapatitis |
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| 中文摘要: |
| 用酚妥拉明、当归素治疗慢性活动性肝炎(慢活肝)胆汁郁滞及慢性重症肝炎共60例。部分病例用肝血管造影数字减影法(DSA)观察酚妥拉明用药前后血管床的变化,以及当归素对血小板聚集性的作用。结果表明,滴注酚妥拉明后肝窦显影范围较用药前扩大,肝窦周围末梢静脉分枝增多、增粗,提示酚妥拉明能改善肝循环,当归素有对抗血小板二相聚集的作用。慢性重症肝炎治疗组的存活率为57.14%,对照组为31.82%(P<0.05)。 |
| 英文摘要: |
| Among 60 patients with chronic active hepatitis B,43 were of the severe type,17 were of cholestasis type.Each type was divided randomly into two groups:therapeutic and control.The former received both conventional supporting therapy and combination of phentolamine(20～30 mg/ day)and angelicini(150～450 mg/day).The latter was only treated with conventional supporting therapy.Digital substraction angiography(DSA)and platelet agglutination test were performed in 10 patients respectively.DSA demonstrated that liver sinosoids were expanded and the vascular bed round the sinosoids were also enlarged in diameter following instillation of phentolamine,It was also shown that angelicini could suppress the second phase of platelet agglutination.These indicated that phentolamine and angelicini could improve the liver microcirculation in different way.The incidence of survival between therapeutic and the control group was 57.14% and 31.82% respectively(P<0.05). |
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