免疫性血小板减少性紫癜辨证分型与血小板表面相关抗体及T淋巴细胞亚群的关系

The Research of the Relationship between the Type of Asthenia of both Spleen and Kidney and PAIg and T Lymphocyte Subsets of Idiopathic Thrombocytopenic Purpura

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中文关键词: 免疫性血小板减少性紫癜脾肾亏虚证脾虚失统型脾肾阴亏型血小板相关抗体 T淋巴细胞亚群

英文关键词:idiopathic thrombocytopenic purpura asthenia of both Spleen and Kidney PAIg,T lymphocyte subsets

基金项目:

作者	单位
詹文彦	河北邯郸市中医院
魏福玲	河北邯郸市中医院
黄振翘	上海中医学院附属岳阳医院
薛志忠	上海中医学院附属岳阳医院
姚楚芳	上海中医学院附属岳阳医院
周永明	上海中医学院附属岳阳医院

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中文摘要:

为探讨免疫性血小板减少性紫癜（ITP）中医辨证分型与免疫机理的关系,将ITP患者中医辨证分型结合血小板相关抗体（PAIg）及T淋巴细胞亚群进行分析。发现作为本病主要抗体的PAIgG脾肾阴亏型明显高于脾虚失统型（P<0.01）;OKT₈⁺值亦显著高于脾虚失统型（P<0.05）,OKT₄⁺/OKT₈⁺比值则明显低于脾虚失统型（P<0.05）。提示脾肾阴亏型的免疫损伤程度较脾虚失统型严重。

英文摘要:

Idiopathic thrombocytopenic purpura （ITP） is a kind of disease associated with immunity Atpresent a great quantity of study on ITP has been made on humoral and cellular immunity. But thereare few reports about the relationship between the types based on the differential diagnosis of TCMand immune rationale of ITP. In order to deeply explore the relationship between the types basedon differential diagnosis of TCM and immune rationale of ITP. the authors measured PAIg and Tlymphocyte subsets of 34 ITP patients of asthenia of both Spleen and Kidney. The value of PAIgGincreased in both types of Spleen failing to control blood （SFCh） and deficiency of Spleen-yin andKidney-yin （DSYKY）, and the value of PAIgG of the type of DSYKY was significantly higher thanthat of SFCB （P<0.01）. OKT₃, OKT₄/OKT₈ of the type of SFCB remarkably decreased （P<0.05）, OKT₄ OKT₄/OKT₈ of DSYKY also remarkably decreased （P<0.001）, while OKT₈ significantlyincreased （P<0.001）. The above results suggested that the type of DSYKY has more seriousimmune dysfunction than the type of SFCB,and the types of SFCB and DSYKY has close relationshipwith PAIg T lymphocyte subsets.

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