| 戴顺龄,孙仁宇,张宏,孙瑛,斯勤,吴云清,薛全福.山莨菪碱治疗大鼠肺水肿的实验研究——血气及肺动脉楔压的动态变化[J].中国中西医结合杂志,1992,(6):359-361,326 |
| 山莨菪碱治疗大鼠肺水肿的实验研究——血气及肺动脉楔压的动态变化 |
| An Experimental Study of Anisodamine on Therapeutic Effect of Pulmonary Edema in Rats |
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| DOI： |
| 中文关键词: 肺水肿 肺动脉楔压 动脉氧分压 血氧饱和度 二氧化碳分压 山莨 菪碱 |
| 英文关键词:anisodamine pulmonary edema pulmonary wedge pressure blood gas |
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| 中文摘要: |
| 在肾上腺素所致大鼠肺水肿实验中,发现肺动脉楔压（PAWP）增加4.2倍,颈动脉压（CAP）增加1.0倍,动脉氧分压（PaO2）、血氧饱和度（O2Sat）明显下降,二氧化碳/分压（PaCO2）明显上升,动物均在15min内死亡。用中药山莨菪碱治疗后,30mm内异常的PAWP、CAP、PaO2、O2Sat、PaCO2均逐渐趋于正常,动物全部存活。实验证明山莨菪碱对肺水肿有明显治疗作用。 |
| 英文摘要: |
| The pulmonary edema （PE） induced by adrenaline （AD） is similar to neurogenic pulmonary edema. Anisodamine （654） showed an apparent therapeutic effect on it. The pulmonary wedge arterial pressure （PAWP）, carotid arterial pressure （CAP） and blood gases were measured. It was fonnd that in PE group ,PAWP was increased to four-fold compared with those from before AD administration （from 0.98±0.24 to 4.04±0.53 kPa, X±SD） rapidly. CAP was increased to one fold. The changes of PaO2,O2Sat and PaCO2 showed progressive hypoxia. The PaO2（kPa）was 11.0±1.3, 6.1±1.7, 4.4±1.9 and 3.8±1.9,PaCO2（kPa） was 4.1±2.1, 5.4±0.8, 9.7±2.9 and 10.3±3.4, O2 Sat（%） was 95.6±16.0, 69.2±15.1, 48.9±22.0,and 33.7±25.9 in order before AD injection,15 min after AD injection and before death respectively. Blood pH value also decreased in apparent way. All of animal died within 15 min. While in 654-2 therapeutic group, the significant increased PAWP and CAP were decreased gradually to normal within 30 min. The abnormal blood gases and pH were approached to repair within 20 min. All of animals survived. |
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