缩泉丸治疗氯氮平所致流涎的临床观察

作者	单位
康冰	南京神经精神病防治院江苏 210029
刘玉成	南京神经精神病防治院江苏 210029
张雅萍	南京神经精神病防治院江苏 210029
韩玉	南京神经精神病防治院江苏 210029
樊禄珍	南京神经精神病防治院江苏 210029
周军	南京神经精神病防治院江苏 210029

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中文摘要:

采用双盲法观察缩泉丸治疗氯氮平所致流涎的疗效。缩泉丸治疗组21例,治疗后流涎症状较19例对照组明显减少(P<0.01)。中医辨证分型与缩泉丸治疗关系分析,表明痰湿内阻型和阳虚亏损型疗效最佳。氯氮平血浓度与流涎两者间无相关性(P>0.05)。

英文摘要:

40 Schizophrenic inpatients with clozapine induced salivation were divided into two groupsrandomly. They were treated with Suo Quan pill and a control study of the placebo (neutral pill) forreducing clozapine induced salivation. These cases were also classified by TCM Syndrome Differen-tiation and laboratory examinations were performed. Results: There was a significant difference ineffect on salivation between the therapeutic group (21 cases) and the controlled group (19 cases), P<0.01. According to their TCM subtypes two subtypes (Stagnation of Phlegm-Dampness and YinDeficiency) showed the best results. No correlation between the peripheral clozapine level andsalivation was found. No side effect was recorded.

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