顾明君,刘志民.川芎嗪对环孢素引起的大鼠胰岛β细胞毒性防护作用的实验研究[J].中国中西医结合杂志,1993,(9):542-543,517 |
川芎嗪对环孢素引起的大鼠胰岛β细胞毒性防护作用的实验研究 |
Prevention of Toxicity of Cyclosporine A on Rat Pancreatic Islet Beta-Cells by Ligutrazine |
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DOI: |
中文关键词: 川芎嗪 环孢素 胰岛β细胞 |
英文关键词:cyclosporine A ligustrazine pancreatic islet beta-cell |
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中文摘要: |
给大鼠应用环孢素(CsA)50mg/kg·d灌胃,共10天,引起高血糖症及血浆和胰腺组织中胰岛素水平下降。同时联合应用川芎嗪(LIG)50mg/kg·d共10天,能有效地防止和(或)减轻CsA引起的上述变化。LIG还有效地减轻了CsA引起的尿血栓素B2和尿血栓素B2/6-酮-前列腺素F1α值的升高。结果提示LIG对CsA引起的胰岛β细胞毒性的防护作用可能与调节前列胰素代谢有关。 |
英文摘要: |
The toxic effect of cyclosporine A (CsA) on pancreatic islet beta-cells and the preventive effect of ligustrazine (LIG) on CsA-associated beta-cell toxicity in SD rats were investigated. The oral administration of CsA 50 mg/kg/day for ten days caused hyperglycaemia and lowering of plasma and pancreatic insulin levels that were prevented and/or minimized by the combined intra-per-itoneal administration of LIG 50mg/kg/day. An increase of urinary thromboxane B2 (TXB2) and urinary TXB2/6-keto-prostaglandin F1α (6-k-PGF1α) ratio in CsA-treated rats could also be prevented and/or minimized by the administration of LIG. The results suggested that the preventive effect of LIG on CsA-associated islet beta-cell toxicity was relevant to the improvement of prostacyclin-thromboxane A2 imbalance. |
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