血栓闭塞性脉管炎氧自由基与前列环素的变化及其与中医辨证分型的关系

作者	单位
葛金文	湖南中医学院活血化瘀研究室
江一平	湖南中医学院活血化瘀研究室
李安国	湖南中医学院活血化瘀研究室
邓常青	湖南中医学院活血化瘀研究室
贺石林	湖南医科大学检验系
肖德安	湖南马王堆脉管炎专科医院

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中文摘要:

对56例血栓闭塞性脉管炎（TAO）患者血浆丙二醛（MDA）、6-酮-前列腺素F_1α(6-Keto-PGF_1α)含量和红细胞超氧化物歧化酶（Ery-SODA）检测结果表明:和健康对照组比较,TAO组MDA升高,6-Keto-PGF_1α和Ery SODA隆低,差异有显著性意义（P<0.01）:且6-Keto-PGF_1α含量与Ery-SODA和MDA显著相关（P<0.01）;Ⅲ期与Ⅱ期比较,6-Keto-PGF_1α、Ery·SODA下降明显（P<O.05,P<0.01）,MDA上升显著（P<0.01）;与寒证组比较,热证组Ery-SODA下降显著（P<0.01）,6-Keto-PGF_1α下降明显（P<0.05）,而MDA上升显著（P<0.01）。提示,TAO患者脂质过氧化反应剧增,并可能参与血管内皮细胞（VEC）损伤,上述指标可望为TAO辩证提供辅助依据。

英文摘要:

Malondialdehyde （MDA） and 6-keto-PGF₁α levels in plasma and erythrocyte superoxide dis-mutase activities （Ery-SODA） were observed in 56 cases of thromboangiitis obliterans （TAO）. Theresults showed that: （1） Ery-SODA and 6-keto-PGF₁α levels lowered and MDA raised significantlyin TAO （P< 0.01）, compared with that in control. （2） 6-keto-PGF₁α levels were markedly relatedwith Ery-SODA and MDA in TAO （P< 0.01）. （3） Ery-SODA and 6-keto-PGF₁α levels were lowerand MDA higher in Ⅲ phase of TAO than that in Ⅱ phase. （4） Ery-SODA and 6-keto-PGF₁α levelsmarkedly declined and MDA contents elevated significantly in Dampness-Heat （DH） and Heat-Toxin （HT） group, compared with that in Yin-Cold （YC） group and Blood-Stasis （BS） group,respectively （P< 0.05, P< 0.01）; all above substances between YC and BS group or between DH andHT group had no significant differences （P> 0.05）. （5） Ery-SODA and 6-keto-PGF₁α levels werelower and MDA higher in Heat Syndrome than that in Cold Syndrome （P< 0.01）. It suggested thatoxygen free radical and lipid peroxide response that might participate in vascular endothelial cellinjury in TAO markedly increased and the detection of these substances might provide complemen-tary evidences for syndrome differentiation of TAO.

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