| 富杭育,周爱香,查显元,郭淑英.桂枝汤对体温双向调节作用的机理探讨——对下丘脑前列腺素E2的影响[J].中国中西医结合杂志,1993,(11):667-669,645 |
| 桂枝汤对体温双向调节作用的机理探讨——对下丘脑前列腺素E2的影响 |
| Mechanism of Guizhi Tang on Dual-Directional Thermoregulation —Effect on PGE Level in Hypothalamus of Rats |
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| DOI： |
| 中文关键词: 桂枝汤 体温双向调节 前列腺素E2 |
| 英文关键词:Guizhi Tang dual-directional thermoregulation PGE2 |
| 基金项目:国家中医药管理局重点课题资助项目 |
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| 中文摘要: |
| 灌胃给予桂枝汤10g/kg,可使酵母致热大鼠的体温下降,使安痛定引起体温低下大鼠的体温升高。用放射免疫法测定下丘脑和血浆的前列腺素E2（PGE2）含量,在发热动物中,桂枝汤灌胃使PGE2水平下降;在低温动物中,桂枝汤使PGE2水平提高;灌胃给予桂枝汤对PGE2脑室注射致热大鼠,也有快速解热作用。提示桂枝汤可能通过促进或抑制中枢发热介质PGE2的代谢而参与对体温的双向调节。 |
| 英文摘要: |
| Antipyretic action was found in febrile rats induced by yeast, and body temperature waselevated in hypothermia rats induced by aminopyrine, when 10g/kg of Guizhi Tang （GZT） wasadministered per os. The content of prostaglandin E in the hypothalamus of rats was determinedwith the radioimmunoassay. Administration of GZT in 10g/kg p. o. could both decrease the PGE2level of hypothalamic blood in febrile rats, and increase the PGE2 level in hypothermia rats.Antipyretic action of GZT was also displayed when microinjection of PGE2 into the lateral ventriclewhich produced fever in rats. The evidence was provided that GZT might carry out at least part ofthe dual-directional regulating action in body temperature through the promotion or inhibition onPGE2 synthesis, release, or metabolism in the thermoregulatory center. |
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