脾虚大鼠的川芎嗪药物动力学特征与血液流变学研究

作者	单位
黄熙	第四军医大学西京医院
任平	第四军医大学西京医院
文爱东	第四军医大学西京医院
夏天	第四军医大学西京医院
臧益民	第四军医大学生理教研室
宋岭	第四军医大学西京医院
牛国保	第四军医大学生理教研室
王跃民	第四军医大学生理教研室
蒋永培	第四军医大学西京医院

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中文摘要:

从机体对药物作用特征的角度，探索中医证本质。同步研究了健康与利血平致脾虚大鼠的血液流变学及磷酸川芎嗪（ＴＭＰＰ）灌胃后的药物动力学（药动学）。在本实验条件下与健康组相比，脾虚组的药动学特征为：ＴＭＰＰ在体内的空间处置状态由双室变为单室模型；药物浓度值增加（Ｐ＜０．０５、０．０１）；血药浓度－时间曲线下面积（ＡＵＣ）增强（Ｐ＜０．０１）。７项血液流变学指标（Ｐ＜０．０５～０．０１）示脾虚大鼠处于典型的“浓、粘、聚、凝”的血瘀状态。结论：脾主运化、四肢、肌肉与脾之气虚血瘀可能是脾虚大鼠特征性药物动力学的机制之一；为“辩证药动学”假说提供了初步依据。

英文摘要:

In this experiment,the essence of Spleen Deficiency Syndrome(SDS) was explored with the rat model of SDS using tetramethylpyrazine(TMP).120 Wistar rats were divided into two groups,60 each for control and test group,they were treated with normal saline and reserpine respectively.The hemorheological parameters were also studied in 6 each of both groups.The pharmacokinetic properties were investigated in the remaining control group and test group.Results:(1)Twocompartment open model of the control group was turned into that of one-compartment in test group;(2)The SDS model significantly affected the absorption and distribution of TMP in rats.AUC was much higher and serum concentration of TMP increased significantly than that of control.Hemorheological parameters(viscosity of whole blood, fibrinogen,etc.)increased significantly(p<0.05-0.01),it demonstrated that the SDS model was in a state of Blood Stasis.It might be one of the pharmacokinetic mechanisms of TMP in the SDS model of rats.

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