脾虚患者血清游离氨基酸的变化

测定了３２例脾虚患者的血清游离氨基酸（ＦＡＡ）含量，与２０名健康成年人测定值比较，发现前者有明显改变：（１）脾虚患者游离氨基酸总量（ＦＡＡ总量）、必需氨基酸（必需ＡＡ）及支链氨基酸（支链ＡＡ）含量显著低于正常人，游离赖氨酸、缬氨酸、甘氨酸、苏氨酸、色氨酸、异亮氨酸、丝氨酸、丙氨酸及组氨酸９种氨基酸含量亦明显低于正常，尤以前３种为著。（２）ＦＡＡ总量、必需ＡＡ、支链ＡＡ含量与木糖吸收率之间，ＦＡＡ总量与血清总蛋白、白蛋白、淋转率及补体Ｃ３之间，支链ＡＡ与白蛋白之间均呈显著正相关。提示脾虚患者血清多种ＦＡＡ含量降低，可能与肠道吸收不良有一定的关系。患者血清蛋白浓度及免疫功能低下可能与ＦＡＡ水平降低有关。

英文摘要:

Eighteen kinds of serum free amino acid(SFAA)were measured in 32 patients with Spleen-Deficiency(SD) Syndrome.Several obvious changes were noticed as compared with 20 healthy adults:(1)The levels of total FAA,essential amino acids and free branched-chain amino acids of SD group were significantly lower than that of the control group(P<0.01);(2)Total FAA,essential amino acids and branched-chain amino acids were all positively correlated to D-xylose absorptivity,serum protein and immune function.The above results suggested that the decrease of various SFAA level might be related to malabsorption in patients with SD.It is possible that the decrease of serum protein and immune function was due to the lowering of SFAA.

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