扶正升白胶囊提高白细胞数机理多方位研究

作者	单位
周冬枝	西安医科大学第一临床医学院中医科
王晋源	西安医科大学第一临床医学院中医科
周淑意	西安医科大学第一临床医学院中医科

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中文摘要:

本实验观察了扶正升白胶囊对白细胞减少小鼠脾细胞增殖、白细胞介素Ⅱ（ＩＬ－２）活性、脂质过氧化物（ＬＰＯ）含量及雄性大鼠血清睾酮浓度的影响。结果表明，治疗组脾细胞增殖、ＩＬ－２活性、睾酮浓度明显高于对照组（Ｐ＜０．０５～０．０１），ＬＰＯ略有降低，但无统计学意义。其白细胞升高与ＬＰＯ含量无相关，与Ｔ淋巴细胞增殖及ＩＬ－２活性呈正相关。提示该方药升高白细胞的疗效机理可能与促进Ｔ淋巴细胞增殖、提高ＩＬ－２活性、提高睾酮浓度有关，与抗ＬＰＯ无关。

英文摘要:

In order to study the mechanism of the therapeutic effect of Chinese medicine in raising white blood cells, the effects of multiplication of splenocyte of leukopenic mice,the activity of interleukin-2(IL-2),the lipoperoxidant(LPO)content,the concentration of blood serum testosterone of male mice by using Fuzheng Shengbai Capsules(FZSBC) were observed. The result showed that the multiplication of splenocyte, the activity of IL-2, and testoterone level of the experimental group were significantly higher than those of the control group(P<0.05～0.0l),LPO was decreased slightly,which had no statistic significance. Therefore,the increasing of WBC had no relation with the content of LPO but was positively correlated with T lymphocytes as well as the activity of IL-2. This study showed that the mechanism of leukocytogenic effect of FZSBC might be that it was related with promoting the proliferation of T lymphocytes, elevating the activity of IL-2 and raising the testosterone level, but was not relevent with anti-LPO.

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