| 孙林,易著文,虞佩兰.川芎嗪对人胎肾小球系膜细胞增殖的影响及其机理探讨[J].中国中西医结合杂志,1995,(3):134-136 |
| 川芎嗪对人胎肾小球系膜细胞增殖的影响及其机理探讨 |
| Effect of Tetramethylhyrazine on Proliferation of Human Fetal Mesangial Cells |
| 免费下载全文 查看/发表评论 下载PDF阅读器 |
| |
| DOI： |
| 中文关键词: 系膜细胞 增殖 川芎嗪 |
| 英文关键词:mesangial cell proliferation tetramethylhyrazine |
| 基金项目: |
|
| 摘要点击次数: 1384 |
| 全文下载次数: 1285 |
| 中文摘要: |
| 在人胎肾小球系膜细胞（ｍｅｓａｎｇｉａｌｃｅｌｌ，ＭＣ）培养体系中加入川芎嗪后能抑制ＭＣ生长数量。川芎嗪０．６ｍｍｏｌ、１．２ｍｍｏｌ加入ＭＣ培养体系６天后，ＭＣ数量（活细胞个数／ｍｌ）分别为：３７５８０±３４７５，２７３５０±３４１８，明显低于对照组７１８５０±５１０８（Ｐ＜０．０５）；ＭＣ￣３Ｈ－ＴｄＲ摄取量（ｃｐｍ）对照组为３５７５±３０６，加入川芎嗪０．６ｍｍｏｌ、１．２ｍｍｏｌ后分别为１０１７±２０１，５８３±２７１（Ｐ＜０．０１）；加入川芎嗪１ｍｍｏｌ于ＭＣ培养体系中，ＭＣ上清液（１：８稀释度）加入ＫＤ＿（８３）细胞体系中，ＫＤ＿（８３）细胞￣３Ｈ－ＴｄＲ摄取量为２１１８±２１５，明显低于阴性对照组３８９０±２９５与阳性对照组４１２８±３５１（Ｐ＜０．０１）。提示川芎嗪抑制ＭＣ增殖的机理是通过降低ＭＣ自分泌ＩＬ－６而致。 |
| 英文摘要: |
| Tetramethylhyrazine (TMP) 0. 6 and 1. 2 mmol were added to human fetal mesangial cell (MC)cultures for 6 days, and the amounts of MC (cells/ml) were 37580±3475 and 27350±3418 respectively,significantly lower than that 71850±5108 in control (P<0. 05) .The 3￣H-TdR incorporation by the MC with corresponding TMP were 1017±201 and 583±271, also significantly lower,than that 3575±306 in control (P<0. 01) . After adding the TMP (l mmol) to the cultures, the IL-6 bioactivity were 2118±215 that were markedly lower than those in controls (4128±351,P<0 . 01). It revealed that the TMP inhibited the growth of MC and the mechanism of its inhibition might be due to that TMP could reduce the IL-6. |
| 关闭 |
扫描微信二维码，获取更多信息