舒心饮改善冠心病左心室舒张功能障碍的临床研究

作者	单位
陈伟	上海中医药大学附属龙华医院
何燕	上海中医药大学附属龙华医院
林钟香	上海中医药大学附属龙华医院
肖沪生	上海中医药大学附属龙华医院
陈长勋	上海中医药大学附属龙华医院

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中文摘要:

我们应用多普勒超声心动图检查了３１例冠心病左心室舒张功能不全患者在舒心饮治疗前后舒张功能的变化以及临床症状、体征、心电图和血脂的变化。经过１个月的治疗后，患者的症状、体征及心电图较治疗前好转，临床症状有效率为８７．１％，血脂下降（Ｐ＜０．０５）。多普勒超声心动图的主要变化为：Ｅ波峰值由４４．８±１０．８ｃｍ·ｓ－１提高到５７．１±１１．０ｃｍ·ｓ－１（Ｐ＜０．０１）．Ｅ波面积由２６．３±６．９ｍｍ２增加至３２．３±６．７ｍｍ２（Ｐ＜０．０１），Ｅ波减速度自２５７．５±１０６．１ｃｍ·ｓ－２提高至２９６．２±８８．９ｃｍ·ｓ－２（Ｐ＜０．０５）。Ａ／Ｅ比值自１．６２±０．３４下降至１．２８±０．１６（Ｐ＜０．０１），而Ａ波峰值、Ａ波面积以及一些时间指标在治疗前后无明显变化（Ｐ＞０．０５）。以上结果表明，舒心饮主要改善冠心病患者左心室舒张早期功能，提高舒张早期左心室充盈血流速度及充盈血流量；从而改善临床症状及心电图表现。

英文摘要:

There was evidence that abnormal left ventricular diastolic function was common in patients with coronary heart disease which led to symptoms such as dyspnea on exertion,distress in chest etc,even overt congestive heart failure.The changes of left ventricular diastolic function were examined with pulsed doppler echocardiography as well as of clinical symptoms,signs,electrocardiographic findings and plasma lipoprotein after Shuxinyin(SXY) therapy in 31 patients with coronary heart disease and abnormal left ventricular diastolic function.The SXY mainly consists of medicinal herbs capable of tonifying Qi and Yin. After treatment for one month the symptoms, signs and ECG were improved, the symptomatic effective rate was 87.1%.Plasma lipoprotein was reduced(P<0.05).The main changes in doppler echocardiography were as follows.The peak of E wave, the area of E wave and Dec rate increased significantly(P<0.01).The ratio of A wave peak to E wave peak was decreased. The changes in peak of A wave, the area of A wave and time index were insignificant(P>0.05). It was concluded that SXY mainly improved the early left ventricular diastolic functions, increased the peak velocity and volume of rapid left ventricular filling blood flow during the early diastole, and thus alleviated symptoms as well as ECG findings.

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