吴朝栋,李鸣真,张艳萍,林宝英,罗明,徐丽君.中药热毒清对内毒素DIC家兔血浆肿瘤坏死因子α、白细胞介素6水平影响的研究[J].中国中西医结合杂志,1995,(6):356-358 |
中药热毒清对内毒素DIC家兔血浆肿瘤坏死因子α、白细胞介素6水平影响的研究 |
Effects of Reduqing Injection on Plasma TNF-α and IL-6 Levels in Rabbits with Endotoxin-induced DIC |
免费下载全文 查看/发表评论 下载PDF阅读器 |
|
DOI: |
中文关键词: 肿瘤坏死因子α 白细胞介素6 热毒清 弥散性血管内凝血 |
英文关键词:tumor necrosis factor-α interleukin-6 Reduqing disseminated intravascular coagulation |
基金项目:国家中医药管理局资助 |
|
摘要点击次数: 1464 |
全文下载次数: 988 |
中文摘要: |
通过Elisa检测内毒素DIC家兔血浆肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)水平变化,并观察中药热毒清注射液对TNF-α、IL-6水平的影响。结果发现,模型组血浆TNF-α、IL-6水平显著升高,其升高水平和组织、器官的损害程度相一致。运用热毒清作为防治处理后,TNF-α、IL-6水平显著降低,组织、器官的损害也相应较轻。以上结果提示TNF-α、IL-6参与DIC发病机制,中药热毒清通过降低TNF-α、IL-6水平可能对DIC具有防治作用。 |
英文摘要: |
Plasma TNF-αand IL-6 levels of endotoxin-induced DIC in rabbits were measured by ELISA methods.Simultaneously,the effects of Reduqing(RDQ)on TNF-αand IL-6 were also studied.The results showed that TNF-αand IL-6 levels increased markedly in model group,which were confirmed with obvious damage of tissue or organ.Co-administration of RDQ could reduce plasma TNF-αand IL-6 levels,together with mild tissue or organ damage.These results indicated TNF αand IL-6 might be involved in pathogenesis of endotoxin-induced DIC,RDQ might be used in preventing or treating DIC through mechanism of reducing TNF-αand IL-6 levels. |
关闭 |