当归注射液对家兔心肌缺血再灌注损伤的保护作用

作者	单位
陈少刚	汕头大学医学院药理学教研室
李长潮	汕头大学医学院药理学教研室
庄学煊	汕头大学医学院药理学教研室
陈焕昭	汕头大学医学院药理学教研室
石刚刚	汕头大学医学院药理学教研室

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中文摘要:

家兔在结扎冠状动脉左室支前１０ｍｉｎ，经耳缘静脉恒速（０．４ｍｌ／ｍｉｎ）输注当归注射液（５０ｍｇ／ｋｇ，３０ｍｌ），可使心肌缺血再灌注后的左室内压（ＬＶＰ）、左室压最大上升及下降速率(±ｄＰ／ｄｔ_ｍａｘ)均显著高于盐水对照组（Ｐ＜０．０５～０．０１），降低再灌注后血浆磷酸肌酸激酶（ＣＰＫ）活性及丙二醛（ＭＤＡ）含量的升幅（Ｐ＜０．０５～０．０１）。上述结果表明，当归注射液对家兔心肌缺血再灌注时心功能降低及心肌细胞损伤具有明显的保护作用。

英文摘要:

The injection of aqueous extract of Angelica sinensis(AS),50 mg/kg,30 ml,were administered intravenously at a rate of 0.4 ml/min by an infusion pump 10 min before the left anterior descending coronary artery of rabbit was ligated,the LVP and±dp/dtmax of the rabbit heart injured by ischemia/reperfusion in vivo,were significantly higher than those in the control group (N.S.group,P<0.05～0.01),and the level of malon-dialdehyde(MDA) and the activity of creatine phosphokinase (CPK) in the blood plasma were lower than those in the control group remarkablyf(P<0.05～0.01).These results showed that AS exerted obvious protective effects on myocardial dysfunction and myocardial injury induced by ischemia/reperfusion.

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