| 黄熙,蒋永培,臧益民,文爱东,牛国保,王跃民,任平.心血瘀阻犬的川芎嗪药物动力学特征与血流动力学研究[J].中国中西医结合杂志,1996,(6):352-354 |
| 心血瘀阻犬的川芎嗪药物动力学特征与血流动力学研究 |
| Study on Pharmacokinetic Characteristics of Tetramethylpyrazine and Hemnodynamics of Heart Blood Stasis in Dogs |
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| DOI： |
| 中文关键词: 冠状动脉定量狭窄 动物模型 磷酸川芎嗪 心血瘀阻 药物动力学 血流动力学 |
| 英文关键词:quantitative coronary stenosis animal model tetramethylpyrazine phosphate heart blood stasis pharmacokinetics hemodynamics |
| 基金项目:国家自然科学基金 |
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| 摘要点击次数: 1271 |
| 全文下载次数: 1120 |
| 中文摘要: |
| “血瘀辩证药动学”指的是血瘀证的病理生理状态对药动学参数有显著影响。为了验证这一新假说，我们选择冠状动脉定量狭窄（心血瘀阻）动物和磷酸川芎嗪作为工具模型和工具药，同步观察了川芎嗪在对照和动物模型组的药动学和血流动力学。与对照组比较，模型组的川芎嗪血清浓度、血药浓度时间曲线下面积值和ｔ１／２β增高（Ｐ＜０．０１）；其可能机理与冠状动脉狭窄诱导的血流动力学异常有关。 |
| 英文摘要: |
| Blood stasis syndrome pharmacokinetics"means the pathophysiological state of blood stasis syndrome affectes significantly the pharmacokinetic parameters.In order to provide scientific evidence for the new hypothesis,the authors studied the hemodynamic changes induced by quantitative coronary artery stenosis and pharmacokinetics of tetramethylpyrazine(TMP) in dog model with heart blood stasis(HBS) and in normal dog(for control) simultaneously.Compared with healthy dog,serum TMP concentration,drug concentration time, area under curve(AUC) and t1/2β in HBS dog were increased signficantly(p<0.01).The mechanism might be related with the abnormal changes in hemodynamics(include decrease in cardiac output,left ventricular systolic pressure and coronary blood flow, etc.) caused by coronary artery stenosis. |
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