不稳定性心绞痛患者血浆内皮素、一氧化氮水平及中药治疗的影响

观察８１例不稳定性心绞痛（ｕｎｓｔａｂｌｅａｎｇｉｎａ，ＵＡ）患者血浆内皮素（ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）、一氧化氮（ｎｉｔｒｉｃｏｘｉｄｅ，ＮＯ）水平及中药益气活血法治疗的影响。结果：血浆ＥＴ水平与健康人比较未见明显性差异（Ｐ＞０．０５）；治疗前后比较亦未见显著差异（Ｐ＞０．０５）。用或不用硝酸盐类抗心绞痛药患者血浆ＮＯ水平均明显低于健康人水平（Ｐ＜０．０２～０．０ｌ）；经治疗获显效的患者血浆ＮＯ水平有所上升，接近健康人水平（Ｐ＞０．０５）。提示ＮＯ在ＵＡ中起着重要作用；硝酸盐类抗心绞痛药物至少部分地依赖血管内皮的完整性；益气活血法的疗效机理可能与改善血管内皮细胞功能，促进ＮＯ释放有关。

英文摘要:

Levels of plasma endothelin (ET) and nitric oxide (NO) in 81 patients with unstable angina and the influence of Chinese herbal medicine for supplementing Qi and activating blood circulation on them were observed. Results showed that the plasma ET level of patient was not significantly different from normal, P > 0 . 05, and it was unchanged after treatment, P> 0. 05. But whether taken nitroglycerin or not, the average level of NO of patients were all lower than that of healthy person (P < 0 . 02 ￣ 0 . 01). After treatment.NO level of the 33 markedly improved patients were elevated and approached the normal level,compared with healthycontrol group, P > 0 . 05. It suggested that the NO played important role in pathogenesis of unstable angina. Action of antiangina drugs such as nitrates,was at least partially depended on integrity of vascular endothelia and the mechanism of effect of Chinese herbal medicine might be related with improving the function of endothelial cells and enhancing the release of NO.

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