脉络宁拮抗庆大霉素耳蜗毒性的实验研究

为了更好地预防庆大霉素中毒性耳聋的发生，通过给豚鼠肌肉注射脉络宁注射液，以脑干听觉诱发电位Ⅲ波潜伏期及外毛细胞计数为指标，观察了脉络宁对庆大霉素中毒性耳损害的影响。结果发现肌肉注射脉络宁可明显减轻庆大霉素耳损害，脉络宁组和庆大霉素组用药后动物的脑干听觉诱发电位Ⅲ波潜伏期分别较实验前延长，为３．０４±０．１２ｍｓ和３．２５±０．８１ｍｓ（ｘ±Ｓ，下同）；耳蜗柯蒂氏器第二回外毛细胞计数分别为１９６．４３±４０．４８个和１４３．２８±３４．５６个。表明脉络宁对庆大霉素耳蜗毒性有拮抗作用。

英文摘要:

In order to prevent the ototoxicity of gentamycin (GE), the effects of Mailuoning (MLN) on the ototoxicity induced by GE in guinea-pigs was observed by injecting the MLN into the animal and comparing the difference in the brainstem auditory evoked potentials (BAEPs) as well as the count of outer hair cells in the second turn of cochlea. The results showed that the ototoxicity of GE was delayed by giving the MLN injection. On 16th day after given GE, BAEPs incubation period of Ⅲ wave in the medicated group and control group were 3 . 04± 0. 12 ms and 3 . 25± 0.81 ms respectively.The count of outer hair cells in the second turn of cochlea were 196. 48± 40 . 48 and 143 . 28 ± 34. 56 respectively. The results suggested that MLN might be antagonistic against the ototoxicity of GE in guinea-pigs.

关闭