四君子汤调整小鼠运化功能紊乱的实验研究

目的：为阐明“脾主运化”和“肝主疏泄”的相关性。方法：用小承气汤合并半量饮食塑造小鼠消化功能紊乱模型，选择补益方剂四君子汤，观察其对小鼠小肠吸收功能、体重、自主活动以及肝脏线粒体氧化磷酸化效率和细胞能荷的影响，从整体验证该方的作用。结果：小承气汤组小鼠小肠糖吸收功能低下，体重下降，自主活动能力减弱，肝线粒体呼吸控制率（ＲＣＲ）和肝细胞能荷值均低于对照组，而四君子汤组各项指标均有明显改善，大剂量四君子汤组更为显著。提示四君子汤具有纠正胃肠功能紊乱和调整肝脏能量代谢的作用。结论：脾主运化应涉及两方面内容：胃肠消化吸收过程（外运化）以及被吸收的物质在肝脏相互转化和能量的生成过程（内运化）。

英文摘要:

To obServe the Sijunzi Decoction in rectifying the digestive disorder. Methods:Sijunzi decoction (SJZD) was chosen to treat digestive dysfunction in mice. The model was induced by Xiaochengqi decoction and semi-starvation. The effects on the absorptive function of the small intestine, body weight, autonomous activity levels, oxidative phosphorylation of hepatic mitochondrion respiratory control rate (RCR) and cells energy charge were Observed in vivo. Results: The group given Xiaochengqi decoction had lower absorption, decreased body weight, and lower autonomous activity levels, and their hepatic mitochondrion RCR and cell energy chrge were also lower than those of the control group. The flewes for the group given SJZD all showed improvement, especially the group given the larger dose of SJZD. Conclusion: SJZD could correct Deficiency of the Spleen and Stomach which to some extent is caused by digestive dysfunction So it is considered that the Spleen’s function of transportation and transformation includes two meanings: external transportation and transformation - the digestive and absorptive function of the small intestine, and internal transportation and transformation - the liver’s conversion of nutrients and generate energy (ATP).

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