| 刘爱如,赵东坡,隋在云,吕丽莉.抗青蒿酯钠伯氏疟原虫膜表面Con A结合位点结合量的研究[J].中国中西医结合杂志,1997,(3):160-161 |
| 抗青蒿酯钠伯氏疟原虫膜表面Con A结合位点结合量的研究 |
| Study in the Combining Quantity of Con A-Binding Sites on Membrane Surface of Artesunate-Resistance Strain of Plasmodium Berghei |
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| DOI： |
| 中文关键词: 伯氏疟原虫抗青蒿酯钠株 伴刀豆球蛋白A结合位点 异硫氰酸荧光素－伴刀豆球蛋白A 荧光显微分光光度技术 |
| 英文关键词:plasmodium berghei artesunate-resistant strain concanavalin A-binding sites fluorescein isothiocyanate of Con canavalin A the technique of fluoromicrospectrophotometre |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 目的：研究疟原虫抗青蒿酯钠的产生机理。方法：以异硫氰酸荧光素－伴刀豆球蛋白Ａ（Ｆ－ＣｏｎＡ）为探针，采用荧光显微分光光度技术，对伯氏疟原虫滋养体膜表面的ＣｏｎＡ结合位点结合量进行了测定。结果：抗青蒿酯钠滋养体膜表面的ＣｏｎＡ结合位点结合量明显低于其正常株。结论：抗青蒿酯钠原虫膜表面的糖类已发生了改变。而膜的流动性变化可能是ＣｏｎＡ结合位点结合量改变的原因之一。 |
| 英文摘要: |
| To study the production mechanism of plasmodium berghei (PB) in resisting artesunate. Methods: The combining quantity of Con A-binding sites on membrane surface of PB trophozoite labelled with fluorescein isothiocyanate (FITC) of Con A was determined by fluoromicrospectrophotometer. Results: the combining quantity of PB artesunate-resistance strain (PBAR) was reduced significantly than that of PB nomal strain (P<0.01). Conclusions: The type of glucose in surface membrane of PBAR has changed and the changes of membrane fluidity could be one of the causes of the change in the combining quantity of Con A-binding sites on membrane of PBAR. |
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