银蒺胶囊改善心绞痛(血瘀证)患者左心室收缩功能的临床研究

目的：为探讨银蒺胶囊改善心绞痛患者左心室收缩功能的机理。方法：用三维超声心动图检查了２８例冠心病心绞痛（血瘀证）患者服用银蒺胶囊前后左心室收缩功能的变化。结果：临床症状总有效率为８５．７％；心功能变化：左心室射血分数升高（治疗前为４５．０±４．９％，治疗后为４８．２±３．５％，Ｐ＜０．０５）；其中收缩早期和晚期射血分数均升高（治疗前分别为２２．６±２．１％和８．３±１．２％，治疗后分别为２８．１±３．０％和１０．３±０．９％，Ｐ＜０．０１和Ｐ＜０．０５），左心室节段收缩率＜５％的心肌范围显著降低（Ｐ＜０．０１）。结论：银蒺胶囊可以改善心绞痛（血瘀证）患者左心室收缩早、晚期收缩功能，而且主要提高低收缩率区心肌收缩功能。

英文摘要:

To explore the Yinji Capsule (YJC) in improving the left ventricular systolic function of angina pectoris patients with Blood Stasis Syndrome. Methods: The systolic function of left ventricle (LV)in cardiac cycle of 28 angina pectoris patients with Blood Stasis Syndrome was examined with three-dimensional echocardiograph (3-DE) before and after treatment with YJC. Results: The total symptomatic effective rate was 85. 7%. The changes of LV systolic function were those: left ventricle ejection fraction(LVEF)increased from 45. 0± 4. 9 % to 48. 2± 3. 5% (P<0. 05):EF on early stage and late stage increased from 22. 6± 2. 1 %, 8. 3± 1. 2% to 28. 1 ± 3. 0% and 10. 3±0. 9 % respectively (P< 0. 01, P< 0. 05 ), myocardial region with segment systole (SS) < 5 % decreased significantly (P<0. 01 ). Conclusion: YJC could improve LV systolic function on early stage and late stage in cardiac cycles,and mainly improve the systolic function of the region with low SS of LV.

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