中医药治疗HIV/AIDS血清抗体阴转8例报告

目的：报道用中药后，血清艾滋病病毒抗体阴转的艾滋病毒感染者／艾滋病（ＨＩＶ／ＡＩＤＳ）患者。方法：８例确诊的ＨＩＶ／ＡＩＤＳ患者〔无症状携带者（ＡＣ）、艾滋病（ＡＩＤＳ）各１例，艾滋病相关综合征（ＡＲＣ）６例〕，用中药方剂（８０２、８０６、８０９、８１０、生脉饮、中研一号）后，复查血清抗体和患者免疫功能，以多聚酶链反应扩增（ＰＣＲ）法检查其淋巴细胞核内的ＨＩＶ－ＤＮＡ，并长期随访观察之。结果：用上药治疗８７～４６３天后，复查患者血清艾滋病病毒抗体已转为阴性。用ＰＣＲ法证实，有５例为ＰＣＲ阳性，２例ＰＣＲ阴性，１例３个月后阳转。连续观察１１～４９个月，这种“血清阴性，核内阳性”的情况仍保持不变，这些患者属于免疫静止型ＨＩＶ感染。还发现所有阴转患者均属免疫功能良好者。结论：艾滋病是一种病程可逆转的疾病，阴转现象和免疫功能密切相关，用中药提高免疫功能，可能有助于阴转现象的出现。

英文摘要:

Objective:For the first time,serum anti-HIV antibody negstive conversion was being reported.Methods: Eight confirmed HIV/AIDS patients (AC1,ARC 6, AIDS 1 )were treated with TCM recipes (802, 806, 809, 810,Shengmaiyin, ZY-1), recheck the serum antibody and immunological function and intranuclear HIV-DNA was investigated with PCR amplifying assay and were long-term followed-up. Results: After medication for 87～463 days, seronegative conversion occurred, PCR assay revealed that 5 cases were PCR (+), 2 of them (-), 1 turned seropositive again in the early stage. Observed continuously for 11～49 months,the"serum negative and intranuclear positive"state　maintained. These patients belonged to immunosilent HIV-infection. The immunological function of　all seronegative converted patients were good. Conclusions: AIDS is a reversible disease. Using medicinal herbs to enhance the immune function will facilitate the appearance of seronegative conversion, which has not been reported before, If it could be further confirmed, its mechanism elucidated,this may greatly strengthen the confidence of the patients.

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