中西医结合治疗突发性耳聋64例临床观察

目的：探讨中西医结合方法治疗突发性耳聋的机理。方法：将１４６例突发性耳聋患者随机分为两组，西医治疗组（对照组）８２例，中西医结合治疗组（治疗组）６４例，除西医治疗外加口服中药。结果：治疗组总有效率为９２．１９％，对照组为７５．６１％，两组比较有显著性差异（Ｐ＜０．０１）。结论：中西医结合治疗突发性耳聋是非常有效的方法。其作用机理可能有以下几个方面：（１）降低血液粘度，增加细胞的韧性，使血流通畅。（２）通过增加前列环素Ｉ２（ＰＧＩ２）和降低血栓素Ａ２（ＴＸＡ２）含量使血管扩张，降低血小板聚集性，以利于内耳的血液供应。（３）提高了超氧化物歧化酶（ＳＯＤ）活力，减轻自由基对内耳的损伤。

英文摘要:

Objective: To explore the mechanisms of sudden deafness treated with integrated traditional Chinese and Western medicine (TCM-WM). Methods: One hundred and forty-six patients suffering from sudden deafness were divided into two groups, 64 cases of treated group treated with the method of integrated TCM-WM and the other 82 cases treated with Western medicine alone for control. Results: The toeal effective rate of the treated group was 92. 19%, that of the control group was 75. 61 %. The difference between two groups was significant, P<0. 01. Conclusion: The integrated method is very effective in treating sudden deafness. Its mechanism might be: (1) Decrease the blood viscosity and increase the red blood cell’s tenacity, so that the bind stream is Passing through unimpeded.(2) Decrease the plasma TXA2 level and increase the PGI2 level, keep the blood supply for inner ear. (3) Increase the activity of SOD and clear away the free radicals so as to reduce the damage of inner ear.

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