丹参、川芎嗪、三七治疗失血性休克晚期的实验研究

Observation of Therapeutic Effect by Combined Administration of Salvia Miltiorrhiza, Ligustrazine and Panax Notoginseng on Late Hemorrhagic Shock of Rabbits

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DOI：

中文关键词: 失血性休克丹参川芎嗪三七联合用药

英文关键词:

基金项目:国家自然科学基金

作者	单位
王志维	湖北医科大学第一附属医院心胸外科
高尚志	湖北医科大学第一附属医院心胸外科
程邦昌	湖北医科大学第一附属医院心胸外科
林道明	湖北医科大学第一附属医院心胸外科
姚震	湖北医科大学第一附属医院心胸外科
涂仲凡	湖北医科大学第一附属医院心胸外科

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中文摘要:

目的：探讨丹参、川芎嗪、三七治疗失血性休克晚期的作用机理。方法：本实验按Ｗｉｇｇｅｒｓ法建立失血性休克家兔模型，平均动脉压（ＭＡＰ）５．３ｋＰａ。通过连续监测休克前、休克１２０ｍｉｎ、再灌注６０ｍｉｎ及１２０ｍｉｎ时静脉血液红细胞超氧化物歧化酶（ＳＯＤ）活性、血浆丙二醛（ＭＤＡ）、血液乳酸盐（ＢＬ）及血浆镁离子（Ｍｇ２＋）浓度变化，观察丹参、川芎嗪、三七对失血性休克晚期家兔的疗效。结果：（１）休克１２０ｍｉｎ时ＳＯＤ活性较休克前明显下降（Ｐ＜０．０１），而ＭＤＡ、ＢＬ及Ｍｇ２＋浓度显著升高（Ｐ＜０．０５），提示失血性休克晚期存在氧自由基所致组织细胞脂质过氧化损伤。（２）用丹参、川芎嗪、三七治疗，与对照组同一时间比较能明显增强ＳＯＤ活性（Ｐ＜０．０５或Ｐ＜０．０１），降低ＭＤＡ浓度（Ｐ＜０．０１），以减轻组织细胞脂质过氧化损伤。结论：丹参加川芎嗪及三七加川芎嗪合用与各单一药物组相比，表明合用可达到减半用量，减轻降压、减慢心率等负性作用，但可取得甚至超过各单一药物全量应用的效果。

英文摘要:

Abstract:Objective: To explore the therapeutic mechanism of Salvia miltiorrhize, ligustrazine and Panax notoginseng in treating late hemorrhagic shock in rabbit. Methods: Rabbit hemorrhagic shock models (MPA 5. 3kPa)were set up according to Wiggers’ method and administrated Salvia miltiorrhiza,ligustrazine, Panax notoginseng. The values of blood RBC superoxide dismutase (SOD) and blood lactate (BL), plasma malondialdehyde (MDA) and magnesium (Mg ) were continuously monitored before shock, 120 minutes after shock, 60 and 120 minutes after hydraulic dilatation. Results: (1) In 120 minutes after shock t the level of SOD decreased and the concentrations of MDA, BL, Mg were markedly increased, which indicated that the cell membrane damage caused by oxygen free radicals in rabbit hemorrhagic shock. (2) Salvia miltiorrhiza, Ligustrazine or Panax notoginseng could alleviate lipidperoxidation injury to tissue. Compared with the single drug administration groups, the effects of oxygen free radicals scavangers by combined administration with half dose of 2 drugs were better than the single drug with full dose alone and the side effects such as depression of blood pressure and heart raids would be alleviated. Conclusion: Combined administration of Salvia miltiorrhiza, ligustrazine and Panax notoginsent would half the dosage,the bital pressure depression and heart rate redwtion alleviated and better result obtained.

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