银屑病辨证分型与血小板活化分子CD62P及CD63表达的关系

Relationship between Syndrome Differentiation-Typing and Expression of Platelet-Activation Molecule CD62P and CD63 on Platelets in Psoriatic Patients

免费下载全文查看/发表评论下载PDF阅读器

DOI：

中文关键词: 银屑病中医分型血小板活化分子

英文关键词:psoriasis Syndrome Differentiation and Typing platelet-activation molecule

基金项目:

作者	单位
李冠勇	济南军区总医院皮肤科
刘华昌	济南军区总医院皮肤科
尹格平	济南军区总医院皮肤科
孙晓明	济南军区总医院皮肤科

摘要点击次数: 1192

全文下载次数: 1001

中文摘要:

目的：观察银屑病中医辨证分型与血小板活化的关系。方法：采用流式细胞仪和特异性抗活化血小板单克隆抗体，对不同证型银屑病患者血小板活化分子ＣＤ６２Ｐ（α－颗粒膜蛋白）及ＣＤ６３（溶酶体完整膜蛋白）的表达进行了定量研究。结果：（１）银屑病患者血小板ＣＤ６２Ｐ及ＣＤ６３表达量较健康人显著增高（Ｐ＜０．００１）；（２）ＣＤ６２Ｐ及ＣＤｅ３表达量：血瘀型＞血燥型＞血热型；（３）血燥型患者ＣＤ６２Ｐ及ＣＤ６３表达量显著高于血热型患者（Ｐ＜０．００１）；（４）血瘀型患者ＣＤ６２Ｐ及ＣＤ６３表达量显著高于血燥型患者（Ｐ＜０．００１）。结论：血小板活化可能在血粘度增高、内皮细胞损伤、微循环障碍等方面参与了银屑病血瘀证的发生与发展。

英文摘要:

Objective:To understand the relationship between Syndrome Differentiation-Typing amd platelet activation in psoriatic patients. Methods:ExpreSSion of platelet-activation molecules CD62P (alpha-granule membrane glycoprotein) and CD63 (lysosomal integral membrane protein) on platelets from 36 psoriatic patients with Syndrome Differentation-Typing in TCM and 31 health subjects were investigated by using flow cytometry and specific monoclonal antibodies against activated platelet. Results: (1) Increased expreSSion of CD62P and CD63 on platelets from psoriatic patients was obServed (P<0.001); (2)The expreSSion of CD62P and CD63 was in following order: The group of Blood Stasis>Blood Dryness>Blood Heat; (3)Compared with the group of Blood Heat, increased expression of CD62P and CD63 was observed in the group of Blood Dryness (P<0.001); (4) Compared with the group of Bind Dryness, increased expreSSion of CD62P and CD63 was Observed in the group of Blood Stasis (P<0.001). Conclusion: The platelet activation might play an important role in higher bital viscosity, endothelial cell injury, abnormal microcirculation, which was correlated with Blood Stasis, found in psoriasis.

关闭