左归丸对左旋谷氨酸单钠大鼠下丘脑单胺类递质含量及体重增长的影响

作者	单位
刘彦芳	上海医科大学华山医院
蔡定芳	上海医科大学华山医院
陈晓红	上海医科大学华山医院
沈自尹	上海医科大学华山医院

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中文摘要:

目的：探讨中医肾阴虚与下丘脑弓状核毁坏后中枢单胺类递质代谢的关系。方法；用谷氨酸单钠（ＭＳＧ，出生后２、４、６、８、１０天，４ｍｇ／ｇ皮下注射）造成大鼠弓状核毁坏后继发性下丘脑－垂体－肾上腺（ＨＰＡ）轴功能亢进模型，观察其下丘脑单胺类递质含量和体重增长的变化。结果：新生期大鼠给予ＭＳＧ，成年后下丘脑单胺类递质中多巴胺、去甲肾上腺素等含量显著降低；同时还表现体重减轻、肥胖、鼻－肛长度缩短等生长受抑现象。滋补肾阴名方左归丸能不同程度改善上述异常指标。结论：ＭＳＧ大鼠中枢单胺类递质的代谢异常与中医肾阴虚相关。

英文摘要:

To evaluate the interrelationship between the traditional Chinese medicine the Kidney-Yin Deficiency Syndrome and the metabolism of hypothalamic monoaminic neurotransmitters after the lesion of arcuate nucleus (ARC). Methods: Rats were injected with monosodium glutamate(MSG, at 2, 4, 6, 8, 10 days after born. 4mg/g body weight, s.c.)during the neonatal period, then the contents of hypothalamic monoaminic transmitters were determined with HPLC and the changes of increase of body weight were observed. Results: Decreases in levels of norepinephrine (NE), dopamine (DA) associated with its metabolite, 3, 4-dihydroxyphenyl acetic acid (DOPAC) were observed, while vanillylmandelic acid(VMA), metabolite of NE, serotonin (5-HT)and 5-hydroxyindole acetic acid (5-HIAA)were unchanged. Furthermore, adult rats with neonatal MSG treatment also demonstrated growth retardation, obesity but lower body weight, and shorter length of naso-anal. Zuogui Wan, classical drugs of nourishing and recuperating the Kidney-Yin, relieved the disorder of the metabolism of hypothalamic monoaminic transmitter in MSG-rats. Conclusion: The metabolic disorders of the central monoaminic transmitters may be related with the Deficiency of the Kidney-Yin.

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