活血化瘀汤治疗过敏性紫癜及高凝指数的观察及意义

作者	单位
朱继志	Zhu Jizhi, Zhu Jianjun, Wang Tianyao, et al The Affiliated Hospital of Nantong Medical College, Jiangsu(226001
朱建军	Zhu Jizhi, Zhu Jianjun, Wang Tianyao, et al The Affiliated Hospital of Nantong Medical College, Jiangsu(226001
王天瑶	Zhu Jizhi, Zhu Jianjun, Wang Tianyao, et al The Affiliated Hospital of Nantong Medical College, Jiangsu(226001
杨锦媛	Zhu Jizhi, Zhu Jianjun, Wang Tianyao, et al The Affiliated Hospital of Nantong Medical College, Jiangsu(226001
龚启荣	Zhu Jizhi, Zhu Jianjun, Wang Tianyao, et al The Affiliated Hospital of Nantong Medical College, Jiangsu(226001

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中文摘要:

目的 :为探讨活血化瘀汤治疗过敏性紫癜 (allergicpurpura,AP)的机理及高凝指数变化的意义。方法 :将患者分为两组 ,对照组以西医常规治疗 ,治疗组在西医常规治疗的基础上加服活血化瘀汤治疗 ,比较两组的治愈率 ;同时观察AP患者治疗前后的高凝指数值变化 ,进行统计学分析。结果 :治疗组治愈率为 86% ,对照组治愈率为 48% ,两组比较 ,有显著性差异 ;治疗组治疗后的高凝指数值显著下降 ,与治疗前比较 ,P <0 0 1。结论 :活血化瘀汤通过增加抗凝活性、维护血管内皮完整性、减低血小板聚集性等综合因素作用 ,显著降低AP患者高凝指数 ,明显改善了AP的高凝血状态 ,从而达到提高AP治愈率的效果。

英文摘要:

Objective: To explore the therapeutic mechanism of Huoxue Huayu Decoction (HXHYD) in treating allergic purpura (AP) and the significance of hypercoagulation index (HCI). Methods: Patients of AP were divided into two groups. On the basis of conventional treatment of western medicine, the HXHYD was given to the treated group additionally, and the cure rate, change of hypercoagulation index of patients were compared with those of the control group treated by western conventional treatment alone. Results: The cure rate of the treated group was 86%, higher than that of control group (48%) significantly. HCI of the treated group was lowered markedly after treatment, as compared with that before treatment, the difference was significant (P<0 01). Conclusions: By the comprehensive effect of promoting anticoagulation activity, maintaining the integrity of vascular endothelia and reducing aggregation of platelets, HXHYD could reduce the HCI and improve hypercoagulative state of AP patients, so as to elevate the cure rate significantly.

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