滋肾汤治疗慢性尿酸性肾病的临床研究

目的 :观察滋肾汤治疗慢性尿酸性肾病的临床疗效。方法 :治疗组予以滋肾汤加别嘌呤醇 ,对照组予以单纯别嘌呤醇治疗 ,观察两组治疗前后血尿酸、肾功能、尿蛋白、尿系列微量蛋白、血脂和血液流变学指标的变化。结果 :治疗组 (42例 )总有效率为 92 86% ,对照组(3 0例 )为 66 67% ,两组比较有显著性差异 (P <0 0 1 ) ;治疗组在改善临床症状 ,降低血尿酸、Scr及BUN和尿系列微量蛋白 (β2 M、Alb、NAG、RBP)及尿蛋白定量等方面均优于对照组 (P <0 0 1 )。治疗组对血脂及血液流变学指标的改善亦优于对照组 ((P <0 0 5或P <0 0 1 )。结论 :滋肾汤能降低慢性尿酸性肾病患者的血尿酸 ,碱化尿液 ,减轻肾损害程度 ,改善血脂代谢及血液高凝状态等作用。

英文摘要:

Objective: To observe the ameliorative effect of Zishen Decoction (ZSD) on chronic uric acid nephrosis (CUAN). Methods: The 72 CUAN patients were divided into 2 groups: The group with ZSD treatment, the dose of which was 400 ml/d and group with zyloric as the control, the dose of which was 200mg/d. The treatment lasted for 8 weeks. Results: The genaral effective rate of the ZSD group was 92.86%; and that of the control group Was 66.67%. There was significant difference between the two groups (P<0 01). ZSD treatment reduced the levels of blood uric acid, serum creatinine and blood urea nitrogen and the levels of albumin, β 2-microglobulin and the activity of N acetyl D glucosaminidase in CUAN (P<0 01).The levels of triglyceride and total cholesterol decreased and the levels of high density lipoprotein cholesterol increased in the serum of ZSD treated CUAN (P<0 01). Conclusions: ZSD exerted obviously ameliorative effect on renal function in CUAN.

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