胎羊窘迫时丹参注射液对脐动脉血液动力学的影响

作者	单位
李笑天	Li Xiaotian, Zhuang Yiliang, Chang Cai, et al The Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai (200011
庄依亮	Li Xiaotian, Zhuang Yiliang, Chang Cai, et al The Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai (200011
常才	Li Xiaotian, Zhuang Yiliang, Chang Cai, et al The Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai (200011
吴国强	Li Xiaotian, Zhuang Yiliang, Chang Cai, et al The Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai (200011
沈霖霖	Li Xiaotian, Zhuang Yiliang, Chang Cai, et al The Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai (200011
周光兴	Li Xiaotian, Zhuang Yiliang, Chang Cai, et al The Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai (200011
张珏华	Li Xiaotian, Zhuang Yiliang, Chang Cai, et al The Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai (200011
吕美铭	Li Xiaotian, Zhuang Yiliang, Chang Cai, et al The Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai (200011
时浩	Li Xiaotian, Zhuang Yiliang, Chang Cai, et al The Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai (200011
王宏	Li Xiaotian, Zhuang Yiliang, Chang Cai, et al The Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai (200011

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中文摘要:

目的 :探讨丹参注射液对胎羊窘迫时脐动脉血液动力学的影响。方法 :用妊娠绵羊 (湖羊 ) 3只 ,于妊娠 1 1 6～ 1 2 5天行胎羊股动脉插管达腹主动脉入口水平 ,脐动脉置电磁流量计探头。经导管注射微小明胶颗粒阻塞胎盘 ,建立胎儿窘迫模型 ;通过动脉插管定期注射丹参注射液 2ml,3只羊共 6次 ,记录用药前后脐动脉血流和胎羊腹主动脉血压信号。用快速傅里叶转换把信号转换为输入阻抗频谱 ,计算脐动脉阻力 (R)和阻抗 (Z)。结果 :应用丹参注射液后R明显下降 (P <0 0 5) ,且下降幅度与丹参应用前的R之间有明显的相关性 (r=-0 85,P <0 0 0 1 )。Z无明显的改变。结论 :在胎盘阻塞引起的胎羊窘迫时丹参注射液能降低脐动脉阻力 ;下降的幅度与用药前脐动脉阻力呈正相关

英文摘要:

Objective: To study the effect of Salvia Miltiorrhiza injection (SMI) on umbilical artery hemodynamics during fetal distress in ewe. Methods: Intrauterine surgery were performed at 116～125 gestational days in 3 pregnancy sheep for insertion of vascular catheters at abdominal aorta from femoral artery and for implantation of a electromagnetic flowmetre probe around umbilical artery. Gelatin microsphere injection to abdominal aorta through vascular catheter for obstruction of placental fetal circulation. 2 ml of SMI was used 6 times(2 times each sheep), and the signs of umbilical artery blood flow and wave forms of fetal abdominal aorta blood pressure were recorded before and after injections of gelatin microsphere or SMI. The fast Fourier translation (FFT) was used to turn signs in time domain into powers spectral of input impedance in frequency domain for resistance and characteristic impedance of umbilical artery. Results: After the SMI was injected into fetal abdominal aorta, the resistance of umbilical artery was significantly reduced (P<0 05), and the changes of resistance was significantly relative with the resistance before SMI injected (r=-0.85,P<0 001). But there were no significantly different impedance between before and after SMI treatment (P>0 05). Conclusions: The SMI to fetal abdominal aorta can decrease umbilical artery blood flow resistance and the changes of resistance was significantly relative to that before SMI treatment.

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