复方丹参注射液在冠心病非心脏手术时防治心肌缺血的临床观察

Observation of Preventing and Treating Effect of Salvia Miltiorrhiza Composita on Patients with Ischemic Coronary Heart Disease Undergoing Non Heart Surgery

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中文关键词: 复方丹参注射液冠心病非心脏手术术中心肌缺血

英文关键词:Salvia miltiorrhiza composita coronary heart disease non heart surgery ischemia in operation

基金项目:

作者	单位
周苏宁	Zhou Suning, Shao Wei, Duan Changli, et al Shandong University of TCM, Jinan (250014
邵伟	Zhou Suning, Shao Wei, Duan Changli, et al Shandong University of TCM, Jinan (250014
段长利	Zhou Suning, Shao Wei, Duan Changli, et al Shandong University of TCM, Jinan (250014
蔚青	Zhou Suning, Shao Wei, Duan Changli, et al Shandong University of TCM, Jinan (250014

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中文摘要:

目的：观察复方丹参注射液用于冠心病非心脏手术术中心肌缺血的治疗。方法：冠心病非心脏手术１０８例，随机分为对照组５４例（术中缺血时用硝酸酯类等药物对症治疗），丹参组５４例（术中加入复方丹参注射液治疗）。术中及术毕观察心电图（ＥＣＧ）、心率（ＨＲ）、平均动脉压（ＭＡＰ）、脉搏血氧饱和度（ＳｐＯ２）、手术失血量，以ＥＣＧ做为疗效评定标准。结果：丹参组总有效率为９０７％，对照组总有效率为３５２％（Ｐ＜００１）。丹参组ＨＲ无明显变化，而对照组ＨＲ增快（Ｐ＜００５）。ＭＡＰ、ＳｐＯ２治疗前后或组间比较无显著差异；失血量两组无明显差异。结论：复方丹参注射液对冠心病非心脏手术术中心肌缺血有明显的改善和保护作用，无明显副作用，是安全有效的措施。

英文摘要:

Objective: To observe the preventing and treatming effect of Salvia miltiorrhiza composita (SMC) on patients with ischemic coronary heart disease (CHD) undergoing non heart surgery. Methods: The 108 patients were randomly divided into the control group and treatment group. In the treatment group, each patient of 54 were administered SMC intravenously during the operation. ECG, HR, MAP and SpO 2 were observed and bleeding quantity was measured perioperatively Results: Effective rate of ECG in treatment group was 90.7% (49/54 cases) and the control group was 35.2%(19/54 cases). There was significant difference between the two groups (P<0 01). HR of the treatment group was no great flutter but control group became faster (P<0 05). MAP and SpO 2 of the two groups were no significant difference perioperatively. There was no significant difference to bleeding quantity between the two groups. Conclusions: SMC could effectively improve and protect myocardial ischemia in patients with CHD undergoing non heart surgery, and no side effect was found.

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