补肾、健脾、活血三类中药复方对脑室内注射白细胞介素-1大鼠下丘脑单胺类神经递质变化的影响

Effect of Three Composite Recipes on Content of Monoamine Transmitters in Hypothalamus Induced by Intracerebroventricular Injection of Interleukin 1 of Rats

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中文关键词: 中药复方白细胞介素-1β 脑内注射下丘脑单胺类神经递质

英文关键词:composite recipe interleukin 1β intracerebroventricular injection hypothalamus monoamine transmitters

基金项目:国家自然科学基金

作者	单位
段元丽	上海医科大学中西医结合研究所
张新民	上海医科大学中西医结合研究所
沈自尹	上海医科大学中西医结合研究所
王文健	上海医科大学中西医结合研究所
陈伟华	上海医科大学中西医结合研究所

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中文摘要:

目的：探索补肾、健脾、活血三类中药复方对免疫因子引起的下丘脑单胺类神经递质的不同影响。方法：用侧脑室注射白细胞介素１β（ＩＬ１β），观测大鼠下丘脑匀浆液中单胺类神经递质的变化，建立一个下丘脑单胺类神经细胞功能对免疫因子的反应状态，以此观察三类中药对这一反应状态的不同影响。结果：侧脑室内注射ＩＬ１β能使下丘脑匀浆液中去甲肾上腺素（ＮＥ）含量明显降低；补肾的右归饮能使因侧脑室注射ＩＬ１β引起下丘脑匀浆液中去甲肾上腺素（ＮＥ）含量下降进一步明显降低；而健脾的四君子汤和活血的桃红四物汤则无明显变化。结论：补肾中药能增强下丘脑去甲肾上腺素神经元的活动，未能观察到健脾、活血中药有类似的作用。

英文摘要:

Objective: To explore the different effects of Youguiyin decoction, Sijunzi decoction, Taohong Siwu decoction on the content of monoamine transmitters in the hypothalamus induced by cytokines. Methods: A reactive status of hypothalamic monoamine transmitters to cytokine in rat was built by observing the content change of monoamine transmitters in hypothalamic homogenate after intracerebroventricular (icv) injection of human recombinant interleukin 1β(IL 1β). On this basis, the different effect of three composite recipes on this status was observed. Results: The content of norepinephrine (NE) declined significantly compared with control group after icv injection of IL 1. Compared with IL 1 group, Youguiyin further reduced the content of NE induced by icv injection of IL 1, while Taohong Siwu decoction and Sijunzi decoction did not show any effect on this status. Conclusions: It seems that Youguiyin for tonifying Kidney could increase the reactivity of hypothalamic NE neuron, Sijunzi decoction for invigorating Spleen and Taohong Siwu decoction for promoting blood circulation did not show this effect.

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