炎症因子与十二指肠溃疡寒热辨证的关系

作者	单位
张学智	Zhang Xuezhi, Ji Baoan, Chen Baowen ,et al Institute of Integrated Traditional Chinese and Western Medicine, The First Hospital of Beijing Medical University, Beijing (100034
纪宝安	Zhang Xuezhi, Ji Baoan, Chen Baowen ,et al Institute of Integrated Traditional Chinese and Western Medicine, The First Hospital of Beijing Medical University, Beijing (100034
陈宝雯	Zhang Xuezhi, Ji Baoan, Chen Baowen ,et al Institute of Integrated Traditional Chinese and Western Medicine, The First Hospital of Beijing Medical University, Beijing (100034
谢竹藩	Zhang Xuezhi, Ji Baoan, Chen Baowen ,et al Institute of Integrated Traditional Chinese and Western Medicine, The First Hospital of Beijing Medical University, Beijing (100034

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中文摘要:

目的：探讨炎症因子与十二指肠溃疡的寒热辨证关系。方法：对４８例十二指肠溃疡患者进行中医寒热辨证，胃镜下作胃窦部活检，测定胃粘膜组织白介素８（ＩＬ８）及白介素６（ＩＬ６），并测定肿瘤坏死因子（ＴＮＦ）、丙二醛（ＭＤＡ）、髓过氧化物酶（ＭＰＯ），然后进行对比分析，并与１０例正常胃粘膜活检标本作比较。结果：热证组胃粘膜ＩＬ８、ＴＮＦ、ＭＰＯ及ＭＤＡ较寒证组增多（Ｐ＜００５）；ＩＬ６与寒热辨证无明显关系。结论：炎症因子ＩＬ８、ＴＮＦ、ＭＰＯ及ＭＤＡ与中医寒热辨证有一定的相关性，可能是中医寒热证型形成的物质基础之一。

英文摘要:

Objective: To explore the relationship of cytokines and Cold Heat Syndrome in patients of duodenal ulcer. Methods: Cold Heat Syndrome Differentiation was done in 48 patients of duodenal ulcer, and the levels of interleukin 8 (IL 8), interleukin 6 (IL 6), tumor necrosis factor (TNF), malonyldialdehyde (MDA), marrow peroxidase (MPO) in gastric mucosa biopsy were measured and compared with those of 10 normal subjects. Results: Levels of IL 8, TNF, MPO and MDA in Heat Syndrome were higher than those in Cold Syndrome (P<0 05), while IL 6 level showed no significant relationship with Cold Heat Syndrome. Conclusion: Cytokines IL 8, TNF, MPO and MDA are correlated with Cold Heat Syndrome in duodenal ulcer patients and which might be one of the molecular mechanisms of Cold Heat Syndrome Differentiation.

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