参麦注射液对心力衰竭患者血浆神经肽Y、内皮素和心钠素的影响

作者	单位
吴红金	Wu Hongjin, Lu Yanming, Zhang Qi, et al Beijing Integrated Traditional and Western Medicine Hospital, Beijing (100039
鲁燕鸣	Wu Hongjin, Lu Yanming, Zhang Qi, et al Beijing Integrated Traditional and Western Medicine Hospital, Beijing (100039
张琦	Wu Hongjin, Lu Yanming, Zhang Qi, et al Beijing Integrated Traditional and Western Medicine Hospital, Beijing (100039
张境坤	Wu Hongjin, Lu Yanming, Zhang Qi, et al Beijing Integrated Traditional and Western Medicine Hospital, Beijing (100039
姚全	Wu Hongjin, Lu Yanming, Zhang Qi, et al Beijing Integrated Traditional and Western Medicine Hospital, Beijing (100039
张颖莉	Wu Hongjin, Lu Yanming, Zhang Qi, et al Beijing Integrated Traditional and Western Medicine Hospital, Beijing (100039
赵玉华	Wu Hongjin, Lu Yanming, Zhang Qi, et al Beijing Integrated Traditional and Western Medicine Hospital, Beijing (100039

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中文摘要:

目的:探讨参麦注射液对心力衰竭患者神经内分泌的影响。方法:60例心力衰竭患者,随机分为治疗组和对照组,每组30例,治疗组给予参麦注射液静脉滴注加西医综合疗法,对照组仅给西医综合治疗,观察用药前后心脏功能及血浆神经肽Y(NPY)、内皮素(ET)和心钠素(ANP)的变化。结果:治疗组临床显效率与总有效率明显高于对照组,心力衰竭患者血浆NPY、ET和ANP水平明显高于健康人,治疗后两组患者血浆NPY、ET和ANP水平均降低,治疗组优于对照组。结论:参麦注射液不仅能改善心力衰竭患者的心脏功能,同时可以影响心力衰竭患者的神经内分泌活性。

英文摘要:

To investigate the effect of Shenmai injection (SMI) on neuroendocrine function in the patients with heart failure (HF). Methods: Sixty patients with HF were randomly divided into the treated group administered with SMI combined with western medicine, and the control group administered with western medicine alone. The change of cardiac function was observed, and plasma neuropeptide Y (NPY), endothelin (ET) and atrial natriuretic polypeptide (ANP) were determined by immunoradiometric assay. Results: The total effective rate and markedly effective rate were higher in the treated group than that of the control group, the level of NPY, ET and ANP of both groups were higher than healthy subjects. The plasma NPY, ET and ANP of both groups were significantly reduced after treatment, the effect of treated group was better than that of control group. Conclusion: SMI could improve the HF patient′s cardiac function, reduce the level of plasma NPY, ET and ANP, their neuroendocrine activity was affected at the same time.

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