大承气汤及大黄治疗小鼠细菌性腹膜炎

作者	单位
胡萍	HU Ping, BAI Fengju, LI Dongsheng, et al Department of Pharmacology, Tianjin Medical University, Tianjin (300070
白凤菊	HU Ping, BAI Fengju, LI Dongsheng, et al Department of Pharmacology, Tianjin Medical University, Tianjin (300070
李东升	HU Ping, BAI Fengju, LI Dongsheng, et al Department of Pharmacology, Tianjin Medical University, Tianjin (300070
张才丽	HU Ping, BAI Fengju, LI Dongsheng, et al Department of Pharmacology, Tianjin Medical University, Tianjin (300070
吴咸中	HU Ping, BAI Fengju, LI Dongsheng, et al Department of Pharmacology, Tianjin Medical University, Tianjin (300070

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中文摘要:

目的 :研究腹腔注射大承气汤或其组分大黄对小鼠抗菌能力的影响。方法 :于建立细菌性腹膜炎模型前分别腹腔注射大承气汤或大黄煎对小鼠预防治疗 2天后 ,分别腹腔注射大肠杆菌 (10 8/ml)或变形杆菌 (10 6 /ml)建立腹膜炎模型 ,再继续用药治疗 2天。结果 :模型的治疗组小鼠死亡数及相应菌血症发生率明显低于对照组 (P <0 0 5) ,大承气汤和大黄煎对大肠杆菌和变形杆菌感染的小鼠均有良好保护作用。预防加治疗组和模型组治疗后存活鼠心脏血涂片、血培养细菌呈阴性 ,而死亡鼠呈阳性。结论 :大承气汤及大黄有良好的抗菌作用。

英文摘要:

Objective: To observe the antiseptic effect of Dachengqi Decoction (DCQD) or rhubarb, one of the ingredients of DCQD in mice. Methods: The model mice were established by peritoneal injection of Escherichia coli (10 8/ml) or Proteus vulgaris (10 6/ml) respectively. DCQD or rhubarb was given from 2 days before to 2 days after modelling for preventing and treating. Results: The mortality and bacteremia occurrence of the treatment group were significantly lower than those of the control group (P<0 05). Both DCQD and rhubarb showed protective effect on Escherichia. coli or Proteus vulgaris infection in mice. The cardiac blood smear and culture of survival mice in prevention plus treatment group and model group showed negative (bacteria) results but those of dead mice showed positive result. Conclusion: DCQD and rhubarb have excellent bactericidal effect.

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