丹参注射液加胞二磷胆碱治疗高血压脑出血的临床观察

Observation of Therapeutic Effect of Salviae Miltiorrhiza and Cytosine Diphosphate Choline Injection on Patients with Hypertensive Cerebral Hemorrhage

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中文关键词: 高血压脑出血内科治疗丹参注射液

英文关键词:hypertensive cerebral hemorrhage internal treatment Salviae miltiorrhiza injection

基金项目:

作者	单位
于文	上海第二医科大学附属瑞金医院!上海200025
沈帆霞	上海第二医科大学附属瑞金医院!上海200025
马震东	上海第二医科大学附属瑞金医院!上海200025

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中文摘要:

目的:评价丹参注射液在急性高血压脑出血中的治疗作用。方法:将受治的51例高血压脑出血患者(年龄50～78岁,平均612岁)在常规治疗基础上随机分成3组:丹参加胞二磷胆碱(CDPC)组(简称丹参组)、氨甲苯酸(PAMBA)加CDPC组(简称PAMBA组)和单用CDPC组。观察各组临床疗效、血肿吸收率、ADP诱导的血小板聚集率(ADPPag)和凝血酶原时间(PT)及肝、肾功能等情况。结果:采用格拉斯哥预后评分(GOS)方法,丹参治疗组中恢复良好和中等残疾(GR加MD)者占8571%,其他两组分别为4706%和6154%,经χ2检验,有显著性差异(P<005),丹参组临床疗效最佳;丹参组血肿吸收率与PAMBA组及CDPC组比较,经χ2检验,有显著性差异(P<005);丹参治疗组不影响血小板凝血功能,ADPPag、PT在正常范围。结论:丹参注射液是一种治疗急性高血压脑出血安全有效的药物,值得临床推广使用。

英文摘要:

To assess the effect of Salviae miltiorrhiza (SM) injection in the treatment of hypertensive cerebral hemorrhage (HCH). Methods: Fifty one cases (age 50～78 years, 61.2 years on average) of HCH were randomly divided into three groups (SM+cytosine diphosphate choline (CDP C) group and para aminomethyl benzoic acid (PAMBA)+CDP C group as treated group, CDP C group as control group) to observe the outcome of the clinical treatment, hematoma absorbability and changes of ADP platelet agglutination rate (Pag), prothrombin time(PT) and function of the liver and kidney. Results: The rate of good result (GR) and moderate disability (MD) in SM group was 85.71% with the method of Glasgow outcome score (GOS), others were 47.06% and 61.54% separately, they have significant difference, P<0 05. Among them, SM group had best result. Compared the rate of hematoma absorbability of SM group with that of PAMBA, CDP C groups, the difference was significant, P<0 05. It did not affect the platelet coagulative function in SM group. Conclusion: SM injection could effectively improve the condition of patients with HCH, and without any side effect. It is worthwhile to be used in the clinical practice

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