消疲怡神口服液对应激大鼠下丘脑—垂体—肾上腺—胸腺轴影响的实验研究

作者	单位
王琳	WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029
王天芳	WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029
康纯洁	WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029
刘晓兰	WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029
刘燕	WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029
张翠珍	WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029
郑君芳	WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029

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中文摘要:

目的:探讨消疲怡神口服液抗应激的作用机理。方法:观察了消疲怡神口服液对强制冷水游泳大鼠模型血清单胺类物质、肾上腺抗坏血酸和下丘脑垂体单胺类递质含量及胸腺指数的影响。结果:消疲怡神口服液可以拮抗应激所致血清多巴胺、5羟色胺含量升高和肾上腺抗坏血酸含量降低,使降低的下丘脑垂体去甲肾上腺素、5羟色胺含量回升,但对胸腺指数无明显影响。结论:消疲怡神口服液的作用机制与其对机体下丘脑—垂体—肾上腺—胸腺轴的调节有关。

英文摘要:

To investigate the effect of Xiaopi Yishen (XPYS) oral liquid on the rats under repeated forced cold water swimming (RFCWS) stress. Methods: The changes of serum monoamine, ascorbic acid levels in adrenal gland, monoamine levels in hypothalamus and hypophysis, and thymus index were determined. Results: XPYS lowered the increasing of serum DA, 5 HT, improved the reducing of ascorbic acid in adrenal gland and NE, HVA, 5 HT, 5 HITT in hypothalamus and hypophysis of RFCWS stressed rats. Conclusion: The mechanism of XPYS is in connection with the regulation of hypothalamus pituitary adrenal gland thymus axis.

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