金多靶对大鼠胃肠运动的影响及意义

作者	单位
张国平	ZHANG Guoping, JIN Huiming, JIAO Donghai, et al Shanghai Medical University, Shanghai (200032
金惠铭	ZHANG Guoping, JIN Huiming, JIAO Donghai, et al Shanghai Medical University, Shanghai (200032
焦东海	ZHANG Guoping, JIN Huiming, JIAO Donghai, et al Shanghai Medical University, Shanghai (200032
宋海林	ZHANG Guoping, JIN Huiming, JIAO Donghai, et al Shanghai Medical University, Shanghai (200032

摘要点击次数: 1326

全文下载次数: 946

中文摘要:

目的:研究口服减肥降脂药物金多靶对大鼠胃肠运动的影响。方法:Wistar大鼠18只,分成金多靶高、低剂量组(200mg/100g体重、125mg/100g体重)和对照组(蒸馏水)。麻醉后用美蓝作指示剂,打开腹腔直接观察胃排空时间,并直接记录盲肠运动频率与波幅,测定肠内容物移动距离及排便次数。用ELISA法测定血清肿瘤坏死因子(TNFα)浓度。结果:两组大鼠服药后胃排空时间明显延长,肠内容物移动加速,大便次数明显增加,盲肠运动频率、波幅明显增强,肠运动频率与血清TNFα浓度间呈显著负相关(r=-091,P<005)。结论:金多靶能明显延长胃排空时间。金多靶增强肠运动不仅与大便次数增加有关,而且与血清TNFα水平下降显著相关。

英文摘要:

To study the effect of obesity reducing drug Kintop on gastrointestinal movement in rats. Methods: Eighteen Wistar rats were divided into high dose (200mg/100g) Kintop group, low dose (125mg/100g) Kintop group, and control group. After anesthesia, stomach emptying time was directly observed using methylene blue as indicator. The frequency and amplitude of intestinal movement, and movement speed of intestinal content were detected. The serum tumor necrosis factora (TNFα) level was measured by ELISA. Results: After administration of Kintop, the stomach emptying time was prolonged markedly, movement speed of intestinal content accelerated, time of dejection increased, the intestinal movement frequency and amplitude increased. There was a negative correlation between intestinal movement frequency and serum TNFα level (r=-0 91,P<0 05). Conclusions: Kintop could significantly prolong the stomach emptying time, accelerate intestinal movement. These effects are correlated with not only the increased time of dejection but also the lowered serum TNFα level.

关闭