中药复方962胶囊对老年雌、雄性大鼠肝脏过氧化脂质及胸腺脾指数的影响

作者	单位
楚晋	首都医科大学宣武医院药理研究室!北京100053
李斌	首都医科大学宣武医院药理研究室!北京100053
李林	首都医科大学宣武医院药理研究室!北京100053
叶翠飞	首都医科大学宣武医院药理研究室!北京100053
刘汇波	首都医科大学宣武医院药理研究室!北京100053
何士大	首都医科大学宣武医院药理研究室!北京100053

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中文摘要:

目的:研究中药复方962胶囊对老年雌、雄性大鼠肝脏过氧化脂质及胸腺指数和脾指数的影响,从而观察中药复方962胶囊的抗氧化作用和对免疫功能的影响作用。方法:将雌、雄两种性别的大鼠分别设青年对照、老年模型、阳性对照脑复康、962小剂量(09g/kg)、962大剂量(18g/kg)5个组,其中,各给药组均为老年大鼠,采用灌胃给药途径,给药1个月。采用硫代巴比妥酸比色法进行肝脏脂质过氧化测定。用称重法对胸腺指数及脾指数进行测定。结果:962小、大剂量组大鼠的肝脏过氧化脂质(MDA)均低于老年模型组,其中962大剂量组与老年雌性组比较有显著性差异(P<001);962小、大剂量组的胸腺指数均高于老年模型组,其中962大剂量组对老年雌性大鼠胸腺指数的升高作用趋势较大;各给药组与老年模型组脾指数比较均无显著性差异。结论:中药复方962胶囊能减少肝脏脂质过氧化物,增加胸腺指数,有助于延缓衰老过程。

英文摘要:

To investigate the effect of 962 capsule, a TCM compound recipe, on liver peroxidation and weight of thymus and spleen (thymus index, spleen index) in aged rats, and observe the anti oxidation effect and the influence on immunological function in rats. Methods: Rats were divided into young control, aged model, positive control (piracetam), 962 middle (0.9g/kg) dose and high dose (1.8g/kg) groups, and the medicated rats used in each group were aged rats. All tested drugs were administered for 1 month by gastrogavage. The liver peroxidation was determined by thiobarbituric acid method. The thymus index and spleen index were determined by weighing method. Results: Middle and high dose of 962 capsule attenuated liver peroxidation, their liver MDA lowered, increased the thymus index of aged rats. There was no effect on spleen index in all medicated groups. Conclusions: 962 capsule could reduce liver lipid peroxidation and increase thymus index. It is suggested that 962 capsule might be beneficial in retarding aging process.

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