耳炎灵口服液治疗急性卡他性中耳炎的临床和实验研究

作者	单位
张红激	ZHANG Hongji, LI Shuliang, LIU Ruijuan, et al. Xiyuan Hospital, China Academy of TCM, Beijing (100091
李书良	ZHANG Hongji, LI Shuliang, LIU Ruijuan, et al. Xiyuan Hospital, China Academy of TCM, Beijing (100091
刘瑞娟	ZHANG Hongji, LI Shuliang, LIU Ruijuan, et al. Xiyuan Hospital, China Academy of TCM, Beijing (100091
许勇钢	ZHANG Hongji, LI Shuliang, LIU Ruijuan, et al. Xiyuan Hospital, China Academy of TCM, Beijing (100091
刘剑刚	ZHANG Hongji, LI Shuliang, LIU Ruijuan, et al. Xiyuan Hospital, China Academy of TCM, Beijing (100091
白桦	ZHANG Hongji, LI Shuliang, LIU Ruijuan, et al. Xiyuan Hospital, China Academy of TCM, Beijing (100091
夏仁惠	ZHANG Hongji, LI Shuliang, LIU Ruijuan, et al. Xiyuan Hospital, China Academy of TCM, Beijing (100091
吕宝梁	ZHANG Hongji, LI Shuliang, LIU Ruijuan, et al. Xiyuan Hospital, China Academy of TCM, Beijing (100091
寇秋爱	ZHANG Hongji, LI Shuliang, LIU Ruijuan, et al. Xiyuan Hospital, China Academy of TCM, Beijing (100091

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中文摘要:

目的 :研究耳炎灵口服液对急性卡他性中耳炎的疗效与作用机理。方法 :用耳炎灵口服液治疗急性卡他性中耳炎患者 68例 ( 89耳 ) ,并与头孢氨苄片组 34例 ( 4 4耳 )作对照 ;动物实验观察耳炎灵口服液对免疫功能及对豚鼠实验性非化脓性中耳炎的影响。结果 :临床观察中治疗组和对照组愈显率分别为80 9%、70 5% ,总有效率分别为 91 0 %、84 1% ;治疗组疗效高于对照组 ,但差异无显著性 ;而治疗组起效时间明显快于对照组 (P <0 0 5)。动物实验提示本品对小鼠非特异性免疫、细胞免疫、体液免疫有增强作用 ;可减轻模型豚鼠中耳的炎性渗出和粘膜肿胀程度 ,减少炎性细胞渗出。结论 :耳炎灵口服液对急性卡他性中耳炎有良好的治疗作用 ;对正常小鼠机体的免疫功能有调节作用 ;对实验性非化脓性中耳炎豚鼠模型有一定治疗作用

英文摘要:

Objective: To study the clinical effect and mechanism of Eryanling (EYL) oral liquid in treating acute catarrhal otitis media (ACOM). Methods: Sixty eight cases (89 ears) of ACOM in the treated group were treated with EYL and compared with 34 cases (44 ears) in the control group treated with cephalexinum. Experimental study of effect of EYL on immune function in mice and non suppurative otitis guinea pig was also conducted. Results: The total effective rate of the treated group and the control group was 91.0% and 84.1% respectively, and their rate of curing 80.9% and 70.5% respectively, though the effect in the former was better, statistic analysis showed no significance between them. The effect initiated obviously earlier in the treated group than that in the control group. Results of experimental study suggested that EYL could strengthen the nonspecific immune function, cellular immune function and humoral immune function in mice, and reduce the degree of inflammatory exudation and mucosa swollen in guinea pig. Conclusion: EYL has good therapeutic effect in treating ACOM.

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