疏肝健脾法治疗溃疡性结肠炎的临床观察

目的 :观察疏肝健脾法对慢性非特异性溃疡性结肠炎 (UC)患者的治疗作用。方法 :随机分为治疗组 ( 33例 )和对照组 ( 30例 ) ,分别采用宁泄散、柳氮磺胺嘧啶治疗。观察治疗前后临床症候积分改善情况、不同疗程的疗效情况、免疫指标 (C3、IgG、LCT)的变化 ,及 1年后随访的结果。结果 :初始疗效 (治疗 3个月 )及近期疗效 (治疗 9个月后 ) ,治疗组和对照组差异无显著性 (P >0 0 5) ;远期疗效 (治疗后 1年 ) ,治疗组和对照组比较差异有显著性 (P <0 0 5) ;两组在治疗后C3均明显下降 (P <0 0 5,P <0 0 1) ,IgG变化均不明显 ;治疗组的LCT在治疗后明显升高 (P <0 0 1) ,而对照组也略有升高 ,但差异无显著性。结论 :疏肝健脾法对UC有良好、巩固的远期疗效。

英文摘要:

To observe the effect of soothing Liver and activating Spleen method (SLAS) of TCM in treating ulcerative colitis (UC). Methods: Patients were randomly divided into 2 groups, the 33 cases in the treated group were treated with Ningxie Powder (NXP) and the 30 cases in the control group were treated with salicylazosulfapyridine (SASP). The improvement in clinical symptoms scoring, therapeutic effect in various treatment courses, changes in immune indexes as well as the condition in 1-year follow-up were observed. Results: The initial therapeutic effect after 3 months treatment showed insignificant difference between the two groups. However, the effect in the treated group was better than that in the control group both short-term (after 9 months treatment) and long-term (for 1-year follow-up study) (P<0 05). Conclusion: NXP, a Chinese herbal drug for soothing Liver and activating Spleen, shows good and persistent effect in treating ulcerative colitis and has favorable prospect in application.

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