养精汤促排卵的临床及实验研究

作者	单位
刘金星	成都中医药大学
刘敏如	四川省计划生育研究所
宋韬	成都中医药大学附属医院
陆华	四川省计划生育研究所
唐永淑	成都中医药大学附属医院
谭万信	四川省计划生育研究所

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中文摘要:

目的 :观察养精汤促排卵的疗效并探讨其作用机理。方法 :观察养精汤治疗功能性无排卵患者的疗效及治疗前后促性腺激素、性激素、主卵泡直径的变化 ,并通过动物实验观察其对下丘脑单胺类神经递质、β 内啡肽 ( β EOP)及血清性激素、微量元素和子宫内膜及卵巢组织形态学等的影响。结果 :临床观察36例患者 ,排卵率达 61 1% ,血清促卵泡素 (FSH)、促黄体生成素 (LH)、雌二醇 (E2 )较治疗前明显升高 (P <0 0 1,P <0 0 1,P <0 0 0 1) ,主卵泡直径明显增大 (P <0 0 0 1)。实验研究表明养精汤组与生理盐水组比较卵巢各级卵泡总数及黄体数明显增多 ,优势卵泡比重增大。下丘脑单胺类神经递质去甲肾上腺素 (NE)、多巴胺 (DA)含量显著升高 (P <0 0 0 1,P <0 0 5) ,5 羟色胺 ( 5 HT)及 5 羟吲哚乙酸 ( 5 HIAA)显著降低 (P <0 0 1,P <0 0 5) ,NE/DA、NE/ 5 HT比值明显增大 (P <0 0 5,P <0 0 0 1)。下丘脑 β EOP含量显著降低 (P<0 0 5) ,血清雌二醇 (E2 )、孕酮 (P)含量显著升高 (P <0 0 1,P <0 0 5) ,血清锌 (Zn)、铜 (Cu)、铁 (Fe)含量显著升高 ,(P <0 0 0 1,P <0 0 5,P <0 0 5)。结论 :填补肾精的养精汤具有促排卵作用 ,其促排卵可能是通过下丘脑、垂体、卵巢等多环节、多途径的综合作用而实现的

英文摘要:

Objective: To observe the effect of Yangjing Decoction (YJD) to promote ovulation and to explore its mechanism. Methods: The clinical effect of YJD in treating patients of functional non ovulation and changes of gonadotropic hormone, sex hormone and diameter of main follicle before and after treatment were observed. In experimental study, the influence of YJD on monoamine neurotransmitter of hypothalamus, endorphin (β EOP), serum sex hormone, trace element, endometrium and histomorphology of ovary were observed. Results: In the 36 patients observed clinically, the ovulation rate was 61.1%, the serum contents of follicular stimulation hormone (FSH), luteinizing hormone (LH) and estradiol (E 2) increased and the diameter of main follicle enlarged significantly after treatment (P<0 01, P<0 001). The experimental study showed that the totals of follicle at different levels, the corpus luteum and the proportion of superior follicle in ovary were improved obviously in the YJD group as compared with those in the control group. After YJD treatment the hypothalamus contents of monoamine neurotransmitter, including norepinephrine (NE) and dopamine (DA) increased, the 5 hydroxytryptamine (5 HT) 5 hydroxyindoleaceticacid (5 HIAA) and β EOP decreased significantly, and the NE/DA ratio and NE/5 HT ratio elevated obviously (P<0 05, P<0 001). The serum levels of E 2 , P and trace elements, including Zn, Cu and Fe increased significantly (P<0 05, P<0 01). Conclusion: YJD is an effective recipe in promoting ovulation, the effect may be achieved through the multi linked, multi systemetic synthetic effect of hypothalamus, hypophysis and ovary, etc.

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