| 许勇钢,麻柔,胡乃平,刘锋,杨经敏,马玲,胡晓梅.扶正抗白冲剂对微小残留白血病模型小鼠免疫功能及生存期的影响[J].中国中西医结合杂志,2001,(2):123-125 |
| 扶正抗白冲剂对微小残留白血病模型小鼠免疫功能及生存期的影响 |
| Effect of Fuzheng Kangbai Granule on Immune Function and Survival Time in Minimal Residual Leukemia Model in Mice |
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| DOI： |
| 中文关键词: 扶正抗白冲剂 微小残留白血病 免疫功能 |
| 英文关键词:Fuzheng Kangbai Granule minimal residual leukemia immune function |
| 基金项目:国家中医药管理局重点资助课题!(No .92 2 1 53) |
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| 中文摘要: |
| 目的 :研究扶正抗白冲剂 (FZKBG)对实验小鼠免疫功能及生存期的影响 ,探讨FZKBG治疗微小残留白血病 (MRL)的机理。方法 :接种L72 12 细胞 1× 10 6/只 ,接种后第 3天腹腔注射环磷酰胺 2 50mg/kg ,造成MRL模型小鼠 ,分成模型对照组、模型给药组 ,另设正常对照组、正常给药组 ,分别观察各组小鼠淋巴细胞亚群 (CD3+、CD4 +、CD8+)改变 ,免疫器官病理变化和生存期。结果 :与模型组比较 ,FZKBG能明显提高正常小鼠和MRL模型小鼠CD3+、CD4 +、CD8+的百分比和绝对值 (P <0 0 5,P <0 0 1)。且明显延长MRL模型小鼠存活期 ,延长生命率 2 9 6%～ 60 4 %。结论 :FZKBG能明显延长MRL模型小鼠存活期 ,其机理可能是通过提高MRL模型小鼠的免疫功能 ,抑制体内白血病细胞而实现的 |
| 英文摘要: |
| Objective: To observe the effects of Fuzheng Kangbai Granule (FZKBG) on immune function and survival time in minimal residual leukemia (MRL) model mice and study its mechanism. Methods: MRL model mice were established by hypodermic inoculation with L 7212 cells following intraperitoneal injection of cytoxan (CTX)25 mg/kg 3 days later, and divided into the control group and FZKBG group. The changes of T lymphocyte subsets, including CD 3 +、CD 4 + and CD 8 +, and the survival time in model mice were observed. Results: Comparing with the control group, FZKBG could obviously increase both the percentage and absolute value of CD 3 +and CD 4 + lymphocytes and prolong the survival time of model mice, the prolongation rate being 29 6%-60 4%. Conclusion: FZKBG could markedly prolong the survival time of MRL mice, its mechanism might be through elevating the immune function and inhibiting the leukemic cells in model mice. |
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