洁肠合剂治疗小儿霉菌性肠炎临床与实验研究

目的 :研究洁肠合剂治疗小儿霉菌性肠炎的疗效与机理。方法 :对确诊为小儿霉菌性肠炎的患者 ,采用随机方法分为两组 ,治疗组 4 0例给予洁肠合剂 ,对照组 2 0例给予制霉菌素。观察两组治疗前后大便成形时间、止泻时间、大便培养霉菌消失时间。并研究了洁肠合剂对小鼠小肠推进率的影响以及对大便培养白色念珠菌的抑菌试验。结果 :洁肠合剂在对患儿大便成形时间、止泻时间均较对照组为短 (P <0 0 1)。在改善患儿临床症状与体征方面也较对照组为优。同时洁肠合剂能减慢小鼠小肠对墨汁的排空 ;抑菌试验提示洁肠合剂对白色念珠菌敏感。结论 :洁肠合剂是治疗小儿霉菌性肠炎的有效方药

英文摘要:

Objective: To evaluate the therapeutic effect and mechanism of Jiechang Mixture (JCM) in treating infantile mycotic enteritis. Methods: The children patients confirmed to be suffered from mycotic enteritis were divided randomly into two groups: the 40 cases in the treated group treated with JCM and the 20 cases in the control group treated with fungicidin. The time of stool forming, diarrhea relieving and fungi vanishing were observed. The promoting effect of JCM on small intestine motility and the inhibition of JCM on Candida albicans in stool culture were studied experimentally. Results: The time of stool forming, diarrhea relieving and fungi vanishing in the treated group were significantly shorter than those in the control group (P<0 01), and JCM also showed a better effect in improving clinical symptoms and signs of patients than the control. Results of experimental study showed that JCM could abate the ink evacuation of small intestine in mice. The fungi inhibitory test suggested that Candida albicans was susceptible to JCM. Conclusion: JCM is an effective herbal medicine in treating infantile mycotic enteritis.

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