补肾活血中药对乳腺萎缩、增生雌性大鼠乳腺形态结构的影响

Effects of Kidney Reinforcing and Blood Circulation Activating Chinese Medicine on Morphological Structure of Mammary Glands in Models of Mammary Atrophy and Hyperplasia in Female Rats

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中文关键词: 补肾活血中药乳腺发育雌二醇受体孕酮受体

英文关键词:

基金项目:

作者	单位
李培英	广州中医药大学妇科!广州510405
欧阳惠卿	广州中医药大学第一附属医院妇科

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中文摘要:

目的 :探讨补肾活血中药对乳腺萎缩、增生雌性大鼠乳腺组织形态结构的影响及对受体水平的影响机理。方法 :分别用去势和长期大量肌肉注射己烯雌酚的方法建立成年大鼠乳腺萎缩和乳腺增生模型 ,探讨补肾活血中药对乳腺重量指数、乳腺组织结构及乳腺雌、孕激素受体的影响。结果 :(1)补肾活血中药能使萎缩的乳腺组织结构得到明显改善 ,重量指数显著增加 (P <0 0 1) ,乳腺组织胞浆和胞核雌、孕激素受体的数量明显升高 (P <0 0 1,P <0 0 5) ,并使核 /浆雌、孕激素受体比值趋于正常。 (2 )补肾活血中药能够使增生乳腺的重量指数及乳腺结构得到恢复或改善 ,使雌、孕激素核 /浆受体比值均趋于正常。结论 :(1)补肾活血中药能够预防与改善性激素水平低下导致的成年大鼠乳腺萎缩 ,并促进大鼠乳腺发育。 (2 )补肾活血中药与雌激素制剂虽然都具有促进乳房发育的作用 ,但作用途径不同。补肾活血中药治疗乳房发育不良具有应用开发前景。

英文摘要:

Objective: To study the effects and mechanism of Kidney reinforcing and blood circulation activating Chinese medicine (K&B) on morphologic structure of mammary glands in female rat models of mammary atrophy and mammary hyperplasia. Methods: The models of mammary gland atrophy and hyperplasia were established respectively by ovariectomy and diethylstilbestrol injection to observe the changes of gland′s weight index, structure, estradiol receptor (ER) and progesterone receptor (PR) after treated by K&B. Results: (1)K&B could ameliorate the atrophied structure of mammary gland with significant increase of weight index (P<0 01), raise the number of ER and PR in mammary tissue and nuclei (P<0 01, P<0 05), normalize the ratios of ER and PR in plasma and those in nucleus (EnR/EcR and PnR/PcR). (2) K&B could also improve or restore the proliferated structure of mammary gland and its weight index as well as the EnR/EcR and PnR/PcR ratios. Conclusion: K&B has the effects in preventing and improving the mammary gland atrophy induced by hyposecretion of sexual hormone and promoting the development of mammary gland in adult rats. Although both K&B and estrogen can improve the development of mammary gland, their mechanisms are different. There is a bright future of K&B in treating underdevelopment of mammary gland.

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