| 王蓉蓉,刘素宾.补肾化瘀复方对老年人淋巴细胞白细胞介素-2分泌及白细胞介素-2受体表达的影响[J].中国中西医结合杂志,2002,(1):25-27 |
| 补肾化瘀复方对老年人淋巴细胞白细胞介素-2分泌及白细胞介素-2受体表达的影响 |
| Effect of Bushen Huayu Composite on Secretion of Lymphocytic Interleukin-2 and Interleukin-2 Receptor Expression in the Aged |
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| DOI： |
| 中文关键词: 补肾化瘀复方 老年人 淋巴细胞 白细胞介素2 白细胞介素2受体 |
| 英文关键词:Bushen Huayu Composite the aged lymphocyte i nterleukin 2 interleukin 2 receptor |
| 基金项目:国家自然科学基金资助项目 (No .392 70 731 ) |
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| 中文摘要: |
| 目的 :研究补肾化瘀复方对老年人淋巴细胞白细胞介素 2 (IL 2 )分泌及IL 2受体 (IL 2R)表达的影响。方法 :用MTT法和依赖细胞株法检测IL 2活性 ,用FACS 间接免疫荧光法检测 (IL 2R)阳性细胞数 ,将老年组与青年组及老年组用药前后进行比较。结果 :老年组IL 2分泌较青年组明显降低 (P <0 0 1) ,IL 2R阳性细胞数较青年组明显减少 (P <0 0 1)。补肾化瘀复方可使老年人低下的IL 2活性得到提高 (P <0 0 1) ,使减少的IL 2R阳性细胞数得到增加 (P <0 0 5 )。结论 :补肾化瘀复方可使老年人减退的淋巴细胞免疫功能得到改善。 |
| 英文摘要: |
| To study the effect of Bushen Huayu Composite ( BSHY) on interleukin 2 (IL 2) secretion and IL 2 receptor expression in the a ged. Methods: IL 2 was examined by methyl thiazolyl tetrazolium (M TT) method and IL 2 dependent cellular stains, IL 2 receptor expression was ex amined by FACS indirect immunofluorescence. Results: Aging could result in the decrease in lymphocytic IL 2 secretion and IL 2 receptor expression (P<0 01, P<0 05), which could be improved by BSHY (P<0 01, P<0 05). Conclusion: BSHY has significant up regulatory effect on immu ne function of lymphocytes in the aged. |
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