| 林燕萍,马建华,冯尔宥,黄美雅.健骨颗粒对去卵巢大鼠骨质疏松症预防作用的研究[J].中国中西医结合杂志,2002,(5):369-371 |
| 健骨颗粒对去卵巢大鼠骨质疏松症预防作用的研究 |
| Study on Preventive Effect of Jiangu Granule on Osteoporosis in Ovariectomized Rats |
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| DOI： |
| 中文关键词: 骨质疏松症 预防 健骨颗粒 骨密度 内分泌激素 子宫指数 |
| 英文关键词:osteoporosis prevention Jiangu granule bone mineral density hormone uterus index |
| 基金项目:福建省自然科学基金重大项目 (No .C9830 0 0 1 ) ;教育部骨干教师资助计划项目 (No.1 946) |
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| 中文摘要: |
| 目的 :探讨健骨颗粒对实验性Ⅰ型原发性骨质疏松症的预防作用。方法 :运用切除大鼠卵巢方法建立去卵巢骨质疏松症模型 ,采用双能X线骨密度测定法和放射免疫分析法等 ,检测实验鼠骨骼密度、血清骨钙素、雌二醇、降钙素水平以及子宫指数。结果 :健骨颗粒可明显升高骨密度和子宫指数 ,提高血清雌二醇、降钙素水平 ,降低骨钙素含量。结论 :健骨颗粒可通过调节机体相关内分泌功能 ,有效协调钙调节激素 ,降低骨的转换率 ,增加骨密度 ,对Ⅰ型原发性骨质疏松有预防或延缓发生的作用。 |
| 英文摘要: |
| Objective: To investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type Ⅰ. Methods: Osteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E 2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also. Results: JGG could significantly increase BMD and uterus index, improve the levels of E 2 and CT in serum, at the same time reduce the BGP level. Conclusion: JGG can efficiently prevent type Ⅰ primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD. |
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