扶正健脾方对脾虚厌食症患儿微量元素含量及免疫功能的影响

目的 :评价扶正健脾方治疗脾虚厌食症患儿微量元素含量、免疫功能的变化、疗效及应用前景。方法 :用扶正健脾方治疗 130例脾虚厌食症患儿 ,每天 1剂 ,水煎服 ,30天为 1个疗程 ;选择同期健康儿6 0例作为对照组 ,观察每疗程前后T细胞亚群、白细胞介素 2受体 (IL 2R)、免疫球蛋白 (Ig)及微量元素的含量变化。结果 :脾虚患儿治疗前T淋巴细胞亚群异常 ,尤以CD3、CD4 降低明显 ,IgG含量低 ,治疗后CD3、CD4 、CD4 /CD8的比值明显提高 (P <0 0 1) ;IgG、IgA改善明显 ,治疗前后比较差异有显著性 (P <0 0 1) ;治疗后IL 2R接近正常 ,治疗组微量元素Zn、Fe的变化较为明显 ,治疗前后比较差异有显著性 (P <0 0 1)。结论 :扶正健脾方可使脾虚厌食症患儿体液和细胞免疫恢复动态平衡 ,并改善患儿体内微量元素含量

英文摘要:

Objective: To evaluate the efficacy and prospect of Fuzheng Jianpi Recipe (FZJPR) in treating children′s Spleen deficiency anorexia (CSDA) by means of observing its effect on trace element content and immune function. Methods: One hundred and thirty cases of CSDA were treated with FZJPR, one dose per day in decoction, orally taken, 30 days for one therapeutic course. Levels of T lymphocyte subsets, IL 2R, immunoglobulin and trace elements were determined before and after treatment, and compared with those in the control group consisted of 60 healthy children. Results: In the treated group, abnormal figures were shown in T lymphocyte subsets, especially in lowering of CD 3 and CD 4 count before treatment, and IgG content was reduced also. After treatment, CD 3, CD 4, CD 4/CD 8 ratio as well as IgG and IgA were improved significantly (P<0 01), IL 2R percentage approached normal. Moreover, the levels of Zn and Fe changed significantly (P<0 01). Conclusion: FZJPR could improve the trace elements content and immune function in CSDA children, so it is effective in treating CSDA.

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