参芪佛手合剂缩短产程的临床和实验研究

作者	单位
钱静	扬州大学医学院
夏叶玲	扬州大学医学院
郑陆	扬州大学医学院
吴慧玲	扬州市第一人民医院
杨小梅	扬州大学医学院
周丽华	扬州大学医学院
杨寰	扬州市第一人民医院
韩信宁	扬州市第一人民医院

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中文摘要:

目的 :研究参芪佛手合剂促进产程的临床疗效及其作用机理。方法 :参芪佛手合剂于产前产时服用 ,设立对照组 ,观察产程、并发症、产后出血量及胎儿情况 ,并进行小鼠耐缺氧试验、药物镇痛实验、药物对子宫肌运动影响的实验和急性毒性等实验。结果 :临床中药组潜伏期和总产程明显短于对照组 (P <0 0 1) ;呕吐、肠胀气、尿潴留等滞产综合征发生率明显低于对照组 (P <0 0 5 ) ;产后出血量明显少于对照组(P <0 0 5 ) ;对胎儿无不良影响。动物实验表明 :抗疲劳 ,耐缺氧各项试验 ,参芪佛手合剂Ⅰ、Ⅱ组均较对照组明显延长小鼠存活时间 (P <0 0 1或P <0 0 5 ) ;与对照组比较 ,明显提高小鼠痛阈 ,对小鼠醋酸扭体反应有明显抑制作用 (P <0 0 1或P <0 0 5 ) ;该方能增强早孕家兔在体子宫收缩力 ,与对照组比较子宫收缩幅度明显增加 (P <0 0 1) ,而对离体子宫作用不明显。结论 :参芪佛手合剂临床使用能缩短产程 ,减少滞产综合征发生 ,减少产后出血量 ,该方能提高机体抗应激、抗疲劳、耐缺氧能力 ,加强子宫肌张力 ,提高痛阈值 ,安全范围大。

英文摘要:

Objective: To study the clinical effect and mechanism of Shenqi Foshou mixture (SFM) in promoting labor. Methods: Pregnant women were given SFM before and during labor, and the duration of labor, complication, volume of postpartum bleeding and condition of fetus were observed and compared with those in control. Effects of SFM on anoxia tolerance, analgesia, movement of uterus muscle and it toxicity were tested experimentally. Results: As compared with the control group, in the SFM treated group, the latent period, duration of labor were shorter (P<0 01), incidence of prolonged labor syndrome, revealed as vomiting, intestinal distention and urine retention, was lower (P<0 05) and postpartum bleeding lesser. SFM showed no adverse effect on fetus. Experimental study showed that SFM could prolong the survival time of mice in either anti fatigue or hypoxia tolerance test, raise the pain threshold in mice, inbibit the twisting response induced by acetic acid (P<0 01, or P<0 05), strengthen contraction of uterus muscle in vivo in early pregnant rabbits, but showed no significant influence on isolated uterus. Conclusion: SFM could shorten time of laboring, reduce incidence of prolonged labor syndrome, decrease postpartum bleeding, raise the capacity of organism in anti stress, anti fatigue and antihypoxia, strengthen tonus of uterus muscle, up regulate pain threshold with a wide scope of safety.

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