降压胶囊对老年单纯收缩期高血压的影响及其疗效机制探讨

作者	单位
宋春生	中国中医研究院西苑医院
李浩	中国中医研究院西苑医院
刘芳	河南省卫生职工医学院
罗增刚	河南省中医药研究院附属医院
王力	中国中医研究院西苑医院
徐立然	中国中医研究院西苑医院

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中文摘要:

目的:观察降压胶囊对老年单纯收缩期高血压(EISH)的影响,并探讨其治疗高血压的疗效机制。方法:EISH患者62例,按随机数字表分为降压胶囊治疗组(简称治疗组)35例与天麻钩藤颗粒对照组(简称对照组)27例。观察两组治疗前后的症状积分值及4、8周后的血压值,并随机抽取治疗组25例和对照组15例于治疗前后测定血清一氧化氮合酶(NOS)、丙二醛(MDA)含量及血浆神经Y肽(NPY)、血浆内皮素-1(ET-1)浓度。结果:降压疗效:治疗组35例,显效15例,有效12例,无效8例,总有效率77.15％;对照组27例,显效5例,有效8例,无效14例,总有效率48.15％。两组疗效比较差异有显著性(u=2.09,P<O.05)。症状疗效:治疗组35例,显效19例,有效14例,无效2例,总有效率94.29％;对照组27例,显效9例,有效11例,无效7例,总有效率74.07％;两组比较,差异亦有显著性(P<0.05)。两组治疗后4周及治疗后8周均能改善收缩期血压值,且8周后治疗组改善收缩期血压明显优于对照组(t=8.34,P<0.01)。治疗后治疗组血清NOS活性升高,MDA水平降低,作用优于对照组(P<O.01,P<O.05);治疗组血浆NPY、ET-1浓度降低,与对照组比较差异有显著性(均P<O.05)。结论:降压胶囊对EISH有较好的近期及远期疗效,并能使EISH患者NOS活性升高,血清MDA水平降低,血浆NPY及ET-1浓度降低,这可能是其疗?

英文摘要:

To explore the effect and mechanism of Jiangya Capsule (JYC) in treating simple systolic hypertension in aged patients. Methods: Sixty-two patients with simple systolic hypertension were randomly divided into two groups, the 35 patients in the treated group treated with JYC and the 27 in the control group treated with Tianma Gouteng Granule (TGG). The symptomatic score estimated before and after treatment and blood pressure at the 4th and 8th week were observed. Serum livels of nitric oxide synthase (NOS), malonyl-dialdehyde (MDA), plasma level of neuropeptide Y (NPY) and endothelin-1 (ET-1) were determined before and after treatment in 25 patients of the treated group and 15 patients of the control group. Results: In the treated group, treatment showed markedly effective in 15 patients, effective in 12 and ineffective in 8, the total effective rate was 77.15%, while in the control grup, markedly effective in 5, effective in 8 and ineffective in 14 and the total effective rate was 48.15% . Comparison between the two groups showed significant difference (u = 2.09, P<0.05). The blood pressure at the 4th and 8th week were lowered in both groups, but JYC showed a hypotensive effect superior to that of TGG (t = 8.34, P < 0.01). Moreover, JYC was effective in increasing NOS activity, lowering MDA, NPY and ET-1 levels, with the effect superior to that of TGG (P< 0.05 or P<0.01). Conclusion: JYC has good effect in both short-term and long-term, in treating simple systolic hypertension in aged patients, it also could raise the NOS activity, lower the serum MDA level and reduce the concentration of plasma NPY and ET-1 in patients, which may be one of the therapeutic mechanisms.

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