鹌鹑高尿酸血症模型建立及菊苣提取物对其影响的实验研究

作者	单位
刘小青	北京中医药大学基础医学院北京100029
张冰	北京中医药大学基础医学院北京100029
胡京红	北京中医药大学基础医学院北京100029
刘春梅	北京中医药大学基础医学院北京100029
洪庆涛	北京中医药大学基础医学院北京100029
张浩军	北京中医药大学基础医学院北京100029
孔悦	北京中医药大学基础医学院北京100029

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中文摘要:

目的 :塑造与人类代谢类似的高尿酸血症动物模型 ,观察中药菊苣提取物对其影响。方法 :选择鹌鹑作为模型动物 ,以酵母食饵为造模剂 ,塑造高尿酸血症模型 ,动态检测鹌鹑血清尿酸等生化指标 ,观察菊苣提取物对该模型动物血清尿酸水平等的影响。结果 :饲酵母食饵 (15 g/kg) 7天 ,鹌鹑血清尿酸水平明显升高 ,持续 5周。菊苣提取物小剂量给药 7天可明显降低酵母诱发的鹌鹑血尿酸升高和对抗其一过性血糖的增高 ,给药 14天其作用优于阳性对照药苯溴马龙。结论 :(1)该模型是筛选防治高尿酸血症中药及研究其机制较理想的动物模型。 (2 )菊苣提取物有明显的降尿酸作用。 (3)造模机制和药物作用机理有待进一步深入研究。

英文摘要:

Objective: To establish an animal model similar to hyperuricemia of human beings, and to observe the effect of Cichorii extracts (CE). Methods: Quails were used in the experiment, and yeast was selected for modelling. Biochemical parameters as serum uric acid were determined dynamically and effect of CE on serum uric acid level in the model animal was observed. Results: The serum uric acid in model quails increased significantly after being fed with yeast (15g/kg) for 7 days and the high level maintained for 5 weeks. Low dose of CE could lower significantly the yeast induced hyperuricemia and antagonize the transient hyperglycemia. The effect was better than that of positive control benzbnromarone. Conclusion: The yeast induced hyperuricemia model is an ideal model for observing and screening Chinese herbal drugs for prevention and treatment of hyperuricemia. CE has significant uric acid reducing effect. The mechanism of modelling and drugs′effect are remained to be further studied.

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